Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
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Posted ContentDOI
Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala
Jessica L. Zhou,Giordano de Guglielmo,Aaron J. Ho,Marsida Kallupi,Hai-Ri Li,Apurva S. Chitre,Lieselot L. G. Carrette,Olivier George,Abraham A. Palmer,Graham McVicker,Francesca Telese +10 more
TL;DR: It is found that rats with higher addiction severity have excessive GABAergic inhibition in the amygdala, and that hyperpolarizing GABAergic transmission and relapse-like behavior are reversed by pharmacological manipulation of the metabolite methylglyoxal, a GABAA receptor agonist.
Book ChapterDOI
Nicotine, Neural Plasticity, and Nicotine's Therapeutic Potential
Russell W. Brown,W. Drew Gill +1 more
TL;DR: It is clear that agonists at nicotinic receptors have therapeutic potential, but this should be weighed in the context of the effects of nicotine across the brain and its enhancement of neurotrophic factors.
Journal ArticleDOI
Abstinence-Dependent Effects of Long-Access Cocaine Self-Administration on Nucleus Accumbens Astrocytes Are Observed in Male, But Not Female, Rats
TL;DR: In this paper , the effects of long-access self-administration and abstinence on NAc astrocytes separately in male and female rats were investigated, employing a commonly used behavioral approach to investigate the incubation of cocaine craving.
Journal ArticleDOI
Abstinence-Induced Nicotine Seeking Relays on a Persistent Hypoglutamatergic State within the Amygdalo-Striatal Neurocircuitry
TL;DR: In this article , the authors used a contingent nicotine and saline control self-administration model to disentangle the contribution of cue-elicited seeking responding for nicotine after drug abstinence in male Wistar rats.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
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Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
Journal ArticleDOI
The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.