Neuronal activity modifies the DNA methylation landscape in the adult brain
Junjie U. Guo,Dengke K. Ma,Huan Mo,Madeleine Ball,Mi Hyeon Jang,Michael A. Bonaguidi,Jacob A. Balazer,Hugh L. Eaves,Bin Xie,Eric C. Ford,Kun Zhang,Guo Li Ming,Yuan Gao,Hongjun Song +13 more
TLDR
This study quantitatively compared the CpG methylation landscape of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation, and implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system.Abstract:
It has been unclear how extensively neuronal DNA methylome is regulated by activity. In this resource article, the authors use next-generation sequencing methods and quantitatively compare the CpG methylation landscape of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation.read more
Citations
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DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
TL;DR: The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.
Journal ArticleDOI
Global Epigenomic Reconfiguration During Mammalian Brain Development
Ryan Lister,Ryan Lister,Eran A. Mukamel,Joseph R. Nery,Mark A. Urich,Clare A. Puddifoot,Nicholas D. Johnson,Jacinta Lucero,Yun Huang,Andrew J. Dwork,Matthew D. Schultz,Matthew D. Schultz,Miao Yu,Julian Tonti-Filippini,Holger Heyn,Shijun Hu,Joseph C. Wu,Anjana Rao,Manel Esteller,Chuan He,Fatemeh Haghighi,Terrence J. Sejnowski,Terrence J. Sejnowski,M. Margarita Behrens,Joseph R. Ecker +24 more
TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
Journal ArticleDOI
TET-mediated active DNA demethylation: mechanism, function and beyond
Xiaoji Wu,Yi Zhang +1 more
TL;DR: Recent advances in biochemical and structural studies have revealed mechanistic insights into how TET and TDG mediate active DNA demethylation and many regulatory mechanisms of this process have been identified.
Journal ArticleDOI
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
TL;DR: The molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits is discussed.
Journal ArticleDOI
Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
Junjie U. Guo,Yijing Su,Joo Heon Shin,Jaehoon Shin,Hongda Li,Bin Xie,Chun Zhong,Shaohui Hu,Thuc T Le,Guoping Fan,Heng Zhu,Qiang Chang,Yuan Gao,Guo Li Ming,Hongjun Song +14 more
TL;DR: The characteristics of CpH methylation suggest that a substantially expanded proportion of the neuronal genome is under cytosine methylation regulation and provide a new foundation for understanding the role of this key epigenetic modification in the nervous system.
References
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Global Epigenomic Reconfiguration During Mammalian Brain Development
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