Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake
Kirsty L. Smith,Michael Patterson,Waljit S. Dhillo,Sejal R. Patel,Nina M. Semjonous,James Gardiner,Mohammad A. Ghatei,Stephen R. Bloom +7 more
TLDR
Data demonstrate a novel role for NPS in the stimulation of the HPA axis and the effect of intracerebroventricular administration of NPS on behavior, regulation of theHPA axis, and food intake.Abstract:
Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in the modulation of arousal and fear responses. It has also been shown that lateral ventricle administration of NPS causes a significant decrease in food intake. Neuropeptides involved in the modulation of arousal have been shown to be involved in the regulation of the hypothalamo-pituitary adrenal (HPA) axis and food intake. In this study, we have examined the effect of intracerebroventricular (ICV) administration of NPS on behavior, regulation of the HPA axis, and food intake. ICV NPS significantly increased plasma ACTH and corticosterone 10 and 40 min after injection, respectively. A single ICV injection of NPS caused a significant increase in rearing activity as well as ambulatory movement for up to 45 min after injection. We then studied the effect of paraventricular nucleus (PVN) administration of NPS on the regulation of the HPA axis, behavior, and food intake. There was a significant increase in plasma ACTH and corticosterone after a single NPS PVN injection. Incubation of hypothalamic explants with increasing concentrations of NPS caused a significant increase in CRH and arginine vasopressin release. In addition, PVN administration of NPS dose-dependently inhibited food intake in the first hour after injection, although no effect on food intake was seen after this time. PVN administration of NPS caused a significant increase in rearing activity. These data demonstrate a novel role for NPS in the stimulation of the HPA axis.read more
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Role of neuropeptides in anxiety, stress, and depression: from animals to humans.
TL;DR: Based on data obtained in animal studies, neuropeptides and their receptors might be targeted by new candidate neuropharmacons with the hope that they will become important and effective tools in the management of stress related mood disorders.
Journal ArticleDOI
Ghrelin signalling and obesity: at the interface of stress, mood and food reward.
TL;DR: The ghrelinergic system is considered as an effective target for the development of successful anti-obesity pharmacotherapies, which not only affects appetite but also selectively modulates the rewarding properties of food and impact on psychological well-being in conditions of stress, anxiety and depression.
Journal ArticleDOI
Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice
Anna Rizzi,Raffaella Vergura,Giuliano Marzola,Chiara Ruzza,Remo Guerrini,Severo Salvadori,Domenico Regoli,Girolamo Calo +7 more
TL;DR: The effects of in vivo supraspinal NPS in mice are evaluated and it is shown that in vivo NPS produces a unique behavioural profile by increasing wakefulness and exerting anxiolytic‐like effects.
Journal ArticleDOI
Neuropeptide S receptor gene -- converging evidence for a role in panic disorder.
Katharina Domschke,Andreas Reif,Heike Weber,Jan Richter,Christa Hohoff,Patricia Ohrmann,Anya Pedersen,Jochen Bauer,Thomas Suslow,Harald Kugel,Walter Heindel,Christian Baumann,Benedikt Klauke,Christian Jacob,Wolfgang Maier,Jürgen Fritze,Borwin Bandelow,Petra Krakowitzky,Matthias Rothermundt,Angelika Erhardt,Elisabeth B. Binder,Florian Holsboer,Alexander L. Gerlach,Tilo Kircher,Thomas Lang,Thomas Lang,Georg W. Alpers,Georg W. Alpers,Andreas Ströhle,Lydia Fehm,Andrew T. Gloster,Hans-Ulrich Wittchen,Volker Arolt,Paul Pauli,Alfons O. Hamm,Jürgen Deckert +35 more
TL;DR: In this article, a multilevel approach was applied to further elucidate the role of neuropeptide S in the etiology of human anxiety, and the functional NPSR A/T (Asn 107 Ile) variant (rs324981) was investigated for association with panic disorder.
Central Relaxin-3 administration causes hyperphagia in male Wistar rats
Barbara McGowan,Sarah Stanley,Kirsty L. Smith,N. E. White,M M Connolly,James Gardiner,M. A. Ghatei,S.R. Bloom +7 more
TL;DR: A novel role for relaxin-3 in appetite regulation is suggested after it was found that intra-PVN H3 administration significantly increased 1-h food intake in satiated rats in the early light phase and the early dark phase.
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Neuropeptide S: A Neuropeptide Promoting Arousal and Anxiolytic-like Effects
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