Journal ArticleDOI
Neuroprotection for ischaemic stroke: Current status and challenges
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TLDR
A review will analyse the possible reasons for this failure and the new approaches and recommendations to overcome it, as well as novel strategies targeting additional events in ischaemia cascade.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2015-02-01. It has received 192 citations till now. The article focuses on the topics: Stroke & Penumbra.read more
Citations
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Journal ArticleDOI
Neuronal Cell Death.
TL;DR: Which forms of cell death occur in stroke and Alzheimer's disease are reassess, and why it has been so difficult to pinpoint the type of neuronal death involved is discussed.
Journal ArticleDOI
Post-stroke depression: Mechanisms and pharmacological treatment.
TL;DR: This review will address the various areas of epidemiology, pathophysiology, preventive and therapeutic strategies for post‐stroke depression, as well as the effect of depression as risk factor for stroke.
Journal ArticleDOI
Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models.
Li Yang,Bing Han,Zhiting Zhang,Zhiting Zhang,Zhiting Zhang,Shuguo Wang,Ying Bai,Yuan Zhang,Ying Tang,Du Lingli,Ling Xu,Fangfang Wu,Lei Zuo,Xufeng Chen,Yu Lin,Kezhong Liu,Qingqing Ye,Biling Chen,Bin Li,Tang Tianci,Yu Wang,Ling Shen,Guangtian Wang,Minzi Ju,Mengqin Yuan,Wei Jiang,John H. Zhang,John H. Zhang,Gang Hu,Jianhong Wang,Honghong Yao,Honghong Yao +31 more
TL;DR: Rabies virus glycoprotein-circSCMH1-extracellular vesicles afford protection by promoting functional recovery in the rodent and the nonhuman primate ischemic stroke models and demonstrates the basic mechanism of how circRNAs can be therapeutically exploited to improve poststroke outcomes.
Journal ArticleDOI
Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases
Nathan A. Berger,Valérie C. Besson,A. Hamid Boulares,Alexander Bürkle,Alberto Chiarugi,Robert S. B. Clark,Nicola J. Curtin,Salvatore Cuzzocrea,Ted M. Dawson,Valina L. Dawson,György Haskó,Lucas Liaudet,Flavio Moroni,Pal Pacher,Peter Radermacher,Andrew L. Salzman,Solomon H. Snyder,Francisco Garcia Soriano,Robert P. Strosznajder,Balazs Sumegi,Raymond A. Swanson,Csaba Szabó +21 more
TL;DR: In this article, the authors present a preclinical and clinical action plan for the repurposing of PARP inhibitors for non-oncological indications, such as acute ischaemic stroke, traumatic brain injury, septic shock, acute pancreatitis, severe asthma and severe acute lung injury.
Journal ArticleDOI
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications.
TL;DR: In this article, the authors reviewed potential neuronal death pathways, including intrinsic and extrinsic apoptosis, necroptosis, autophagy, ferroptosis and parthanatos, phagoptosis.
References
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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Journal ArticleDOI
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.
James C. Grotta,M Kothari,K.M.A. Welch,Joseph P. Broderick,Barbara C. Tilley,Thomas G. Brott,Marler,Patrick D. Lyden,Paul M. O'Byrne +8 more
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Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.
TL;DR: Using voltage-clamp experiments on mouse spinal cord neurones, it is shown that the voltage-sensitivity of NMDA action is greatly reduced on the withdrawal of physiological concentrations (∼1 mM) of Mg2+ from the extracellular fluid, providing further evidence that Mg 2+ blocks inward current flow through ion channels linked to NMDA receptors.
Journal ArticleDOI
Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
Martin O'Donnell,Martin O'Donnell,Denis Xavier,Lisheng Liu,Hongye Zhang,Siu Lim Chin,Purnima Rao-Melacini,Sumathy Rangarajan,Shofiqul Islam,Prem Pais,Matthew J. McQueen,Charles Mondo,Albertino Damasceno,Patricio Lopez-Jaramillo,Graeme J. Hankey,Antonio L. Dans,Khalid Yusoff,Thomas Truelsen,Hans-Christoph Diener,Ralph L. Sacco,Danuta Ryglewicz,Anna Członkowska,Christian Weimar,Xingyu Wang,Salim Yusuf +24 more
TL;DR: The findings suggest that ten risk factors are associated with 90% of the risk of stroke, and targeted interventions that reduce blood pressure and smoking, and promote physical activity and a healthy diet, could substantially reduce the burden of stroke.
Journal ArticleDOI
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.
TL;DR: It is shown that, at physiological concentrations, urate reduces the oxo-heme oxidant formed by peroxide reaction with hemoglobin, protects erythrocyte ghosts against lipid peroxidation, and protects ERYthrocytes from peroxidative damage leading to lysis.
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