Journal ArticleDOI
Neutrophil Extracellular Traps in Respiratory Disease: guided anti-microbial traps or toxic webs?
TLDR
A review of the current status of neutrophil extracellular traps (NETs) in respiratory diseases is given in this article, with special attention paid to the literature relevant for the paediatric pulmonology community.About:
This article is published in Paediatric Respiratory Reviews.The article was published on 2017-01-01. It has received 35 citations till now. The article focuses on the topics: Neutrophil extracellular traps & Lung injury.read more
Citations
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Journal ArticleDOI
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome.
Elizabeth A. Middleton,Xue-Yan He,Frederik Denorme,Robert A. Campbell,David Ng,Steven P. Salvatore,Steven P. Salvatore,Maria Mostyka,Amelia Baxter-Stoltzfus,Alain C. Borczuk,Alain C. Borczuk,Massimo Loda,Massimo Loda,Mark J. Cody,Bhanu Kanth Manne,Irina Portier,Estelle S. Harris,Aaron C. Petrey,Ellen J. Beswick,Aleah F. Caulin,Anthony J. Iovino,Lisa M. Abegglen,Andrew S. Weyrich,Matthew T. Rondina,Mikala Egeblad,Joshua D. Schiffman,Christian C. Yost +26 more
TL;DR: NETs triggering immunothrombosis may, in part, explain the prothrombotic clinical presentations in COVID-19, and NETs may represent targets for therapeutic intervention.
Journal ArticleDOI
Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine
Dominik Hartl,Rabindra Tirouvanziam,Julie Laval,Catherine M. Greene,David M. Habiel,Lokesh Sharma,Aö Yildirim,Charles S. Dela Cruz,Cory M. Hogaboam +8 more
TL;DR: Recent findings on pulmonary innate immunity are summarized and key pathways relevant for biomarker and therapeutic targeting strategies for acute and chronic diseases of the respiratory tract are highlighted.
Journal ArticleDOI
The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease.
TL;DR: The role of eosinophils in BP is reviewed and a framework for understanding eOSinophil pathogenic mechanisms in mucocutaneous disease is provided.
Journal ArticleDOI
Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality
Hayder M Al-Kuraishy,Ali I Al-Gareeb,Hany Akeel Al-hussaniy,N. A. H. Al-Harcan,Athanasios Alexiou,Gaber El-Saber Batiha +5 more
TL;DR: In this paper , the potential role of neutrophil extracellular traps (NETs) in the pathogenesis of severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and identifying the targeting drugs against NETs in Covid-19 patients was explored.
Journal ArticleDOI
Neutrophil Extracellular Traps in Autoimmunity and Allergy: Immune Complexes at Work.
TL;DR: Two autoimmune diseases in which NETs are undoubtedly major players are focused on, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), and the role of IC-induced NETs in these settings will pave the way for new diagnostic tools and therapeutic strategies.
References
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Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Journal ArticleDOI
Novel cell death program leads to neutrophil extracellular traps
Tobias A. Fuchs,Ulrike Abu Abed,Christian Goosmann,Robert Hurwitz,Ilka Schulze,Volker Wahn,Yvette Weinrauch,Volker Brinkmann,Arturo Zychlinsky +8 more
TL;DR: This novel ROS-dependent death allows neutrophils to fulfill their antimicrobial function, even beyond their lifespan.
Journal ArticleDOI
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Zvi G. Fridlender,Jing Sun,Samuel Kim,Veena Kapoor,Guanjun Cheng,Leona E. Ling,G. Scott Worthen,Steven M. Albelda +7 more
TL;DR: It is suggested that TGF-beta within the tumor microenvironment induces a population of TAN with a protumor phenotype, and depletion of these neutrophils significantly blunts antitumor effects of treatment and reduces CD8(+) T cell activation.
Journal ArticleDOI
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Stephen Clark,Adrienne C. Ma,Samantha A. Tavener,Braedon McDonald,Zahra Goodarzi,Margaret M. Kelly,Kamala D. Patel,Subhadeep Chakrabarti,Erin F. McAvoy,Gary D. Sinclair,Elizabeth Keys,Emma Allen-Vercoe,Rebekah DeVinney,Christopher J. Doig,Francis H. Y. Green,Paul Kubes +15 more
TL;DR: It is proposed that platelet TLR4 is a threshold switch for this new bacterial trapping mechanism in severe sepsis, where NETs have the greatest capacity for bacterial trapping.
Journal ArticleDOI
Extracellular DNA traps promote thrombosis
Tobias A. Fuchs,Alexander Brill,Daniel Duerschmied,Daphne Schatzberg,Marc Monestier,Daniel D. Myers,Shirley K. Wrobleski,Thomas W. Wakefield,John H. Hartwig,Denisa D. Wagner +9 more
TL;DR: It is reported that NETs provide a heretofore unrecognized scaffold and stimulus for thrombus formation and may further explain the epidemiological association of infection with thrombosis.