Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
More filters
Journal ArticleDOI
Defining Improvement in Nonalcoholic Steatohepatitis for Treatment Trial Endpoints: Recommendations From the Liver Forum
Amanda Cheung,Brent A. Neuschwander-Tetri,David E. Kleiner,Elmer Schabel,Mary E. Rinella,Stephen A. Harrison,Vlad Ratziu,Arun J. Sanyal,Rohit Loomba,S. Megnien,Richard Torstenson,Veronica Miller +11 more
TL;DR: Available data on exploratory histological, blood‐based, and imaging pharmacodynamic biomarkers that may reflect meaningful treatment responses and recommendations regarding measurements to be considered in phase 2 and 3 trials as well as during postmarketing monitoring trials are reviewed.
Journal ArticleDOI
Associations between histologic features of nonalcoholic fatty liver disease (NAFLD) and quantitative diffusion‐weighted MRI measurements in adults
Paul Murphy,Jonathan Hooker,Brandon Ang,Tanya Wolfson,Anthony Gamst,Mark Bydder,Michael S. Middleton,Michael R. Peterson,Cynthia Behling,Rohit Loomba,Claude B. Sirlin +10 more
TL;DR: To investigate in adults the associations between histologic features of nonalcoholic fatty liver disease (NAFLD) and quantitative measures derived from diffusion‐weighted imaging (DWI).
Journal ArticleDOI
The intersection of nonalcoholic fatty liver disease and obesity.
TL;DR: New insights into the overlap and differences between obesity and nonalcoholic fatty liver disease (NAFLD) are contributing to advances in diagnosis and treatment of NAFLD.
Journal ArticleDOI
Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment.
TL;DR: This study will provide a description of diagnostic methods and treatments that are currently recommended for non-alcoholic fatty liver disease.
Journal ArticleDOI
Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults
Avishkar Tyagi,Omid Yeganeh,Yakir S Levin,Jonathan Hooker,Gavin Hamilton,Tanya Wolfson,Anthony Gamst,Amir K. Zand,Elhamy Heba,Rohit Loomba,Jeffrey B. Schwimmer,Jeffrey B. Schwimmer,Michael S. Middleton,Claude B. Sirlin +13 more
TL;DR: MRI-M, MRI-C, and MRS showed high intra- and inter-examination hepatic PDFF estimation repeatability in overweight and obese subjects, and may represent real change rather than measurement imprecision.
References
More filters
Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.