Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Journal ArticleDOI
Quantification of liver, pancreas, kidney, and vertebral body MRI-PDFF in non-alcoholic fatty liver disease
Ilkay S. Idilman,Ali Tüzün,Berna Savaş,Atilla Halil Elhan,Azim Celik,Ramazan Idilman,Musturay Karcaaltincaba +6 more
TL;DR: Pancreas and vertebral body MRI-PDFF is well correlated in NAFLD patients and both of them are higher in diabetic patients which may explain increased bone fractures in diabetics.
Journal ArticleDOI
Prospective Evaluation of Hepatic Steatosis Using Ultrasound Attenuation Imaging in Patients with Chronic Liver Disease with Magnetic Resonance Imaging Proton Density Fat Fraction as the Reference Standard
Sun Kyung Jeon,Jeong Min Lee,Jeong Min Lee,Jeong Min Lee,Ijin Joo,Jeong Hee Yoon,Dong Ho Lee,Jae Young Lee,Joon Koo Han +8 more
TL;DR: Investigating the diagnostic performance of 2-D ultrasound attenuation imaging for the assessment of hepatic steatosis in patients with chronic liver disease using magnetic resonance imaging proton density fat fraction as the reference standard found attenuation coefficients at ATI were well correlated with MRI-PDFF and, thus, may provide good diagnostic performance.
Journal ArticleDOI
Non-invasive methods for the diagnosis of nonalcoholic fatty liver disease.
TL;DR: Current data suggest that ultrasound and the fibrosis-4 score are probably the most appealing methods for detecting Steatosis and for distinguishing NASH from simple steatosis, respectively, because of their low cost and relatively high accuracy.
Journal ArticleDOI
Hepatic Steatosis: Etiology, Patterns, and Quantification
TL;DR: Hepatic steatosis can occur because of nonalcoholic fatty liver disease (NAFLD), alcoholism, chemotherapy, and metabolic, toxic, and infectious causes, and Magnetic resonance (MR) elastography and functional evaluation with Gd-EOB-DTPA are becoming important for monitoring this process.
Journal ArticleDOI
Quantitative Imaging Biomarkers of NAFLD
TL;DR: The utility and limitation of conventional US, CT, and MR imaging for the diagnosis of nonalcoholic fatty liver disease are reviewed and recent advances in imaging biomarkers of NAFLD are discussed with an emphasis in multi-parametric quantitative MRI.
References
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David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
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Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
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Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
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Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
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