Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis
Janki Patel,Ricki Bettencourt,Jeffrey Cui,Joanie Salotti,Jonathan Hooker,Archana Bhatt,Carolyn Hernandez,Phirum Nguyen,H. Aryafar,Mark A. Valasek,William Haufe,Catherine A. Hooker,Lisa Richards,Claude B. Sirlin,Rohit Loomba +14 more
TL;DR: It is demonstrated that a relative reduction of 29% in liver fat on MRI-PDFF is associated with a histologic response in NASH, and can be incorporated into designing future NASH clinical trials, especially those utilizing change in hepatic fat quantified by MRI- PDFF, as a treatment endpoint.
Journal ArticleDOI
Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD—A Systematic Review
TL;DR: NAFLD is heterogeneous and that “Obese/Metabolic NAFLD” but not NAFLd due to the PNPLA3 or TM6SF2 genetic variants predisposes to type 2 diabetes and cardiovascular disease.
Journal ArticleDOI
Quantitative proton MR techniques for measuring fat.
Houchun H. Hu,Hermien E. Kan +1 more
TL;DR: The article succinctly describes the principles that differentiate water and fat proton signals, summarizes the advantages and limitations of various techniques and offers a few illustrative examples, and concludes by briefly discussing some future research directions.
Journal ArticleDOI
Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis
Guido M. Kukuk,Kanishka Hittatiya,Alois M. Sprinkart,Alois M. Sprinkart,Holger Eggers,Jürgen Gieseke,Jürgen Gieseke,Wolfgang Block,Philipp Moeller,Winfried A. Willinek,Ulrich Spengler,Jonel Trebicka,Hans-Peter Fischer,Hans H. Schild,Frank Träber +14 more
TL;DR: Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results and are therefore most appropriate for reliable quantification of liver fat.
Journal ArticleDOI
A Pilot Comparative Study of Quantitative Ultrasound, Conventional Ultrasound, and MRI for Predicting Histology-Determined Steatosis Grade in Adult Nonalcoholic Fatty Liver Disease.
Jeremy S. Paige,Gregory Bernstein,Elhamy Heba,Eduardo A. C. Costa,Marilia Fereirra,Tanya Wolfson,Anthony Gamst,Mark A. Valasek,Grace Y. Lin,Aiguo Han,John W. Erdman,William D. O'Brien,Michael P. Andre,Rohit Loomba,Claude B. Sirlin +14 more
TL;DR: Preliminary observations suggest that QUS parameters may be more accurate and provide higher interobserver agreement than CUS for predicting hepatic steatosis grade in patients with NAFLD.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
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Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
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Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
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Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.