Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Journal ArticleDOI
Clinical strategy of diagnosing and following patients with nonalcoholic fatty liver disease based on invasive and noninvasive methods
Masato Yoneda,Kento Imajo,Hirokazu Takahashi,Yuji Ogawa,Yuichiro Eguchi,Yoshio Sumida,Masashi Yoneda,Miwa Kawanaka,Satoru Saito,Katsutoshi Tokushige,Atsushi Nakajima +10 more
TL;DR: This review will highlight recent studies on the diagnosis and staging of NAFLD based on invasive (liver biopsy) or noninvasive (biomarker, scoring systems, US-based elastography and MRElastography) methods.
Journal ArticleDOI
Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study
Jeffrey Cui,Chi-Hua Chen,Min-Tzu Lo,Nicholas J. Schork,Ricki Bettencourt,Monica P. Gonzalez,Archana Bhatt,Jonathan Hooker,Katherine Shaffer,Karen E. Nelson,Michelle T. Long,David A. Brenner,Claude B. Sirlin,Rohit Loomba +13 more
TL;DR: Genes involved with steatosis pathogenesis may also be involved with fibrosis pathogenesis and the proportion of phenotypic variance between two phenotypes accounted for by additive genetic effects and individual‐specific environmental effects is estimated.
Journal ArticleDOI
Standardized Approach for ROI-Based Measurements of Proton Density Fat Fraction and R2* in the Liver
Camilo A. Campo,Diego Hernando,Tilman Schubert,Tilman Schubert,Candice A. Bookwalter,Candice A. Bookwalter,Andrew J. Van Pay,Scott B. Reeder +7 more
TL;DR: Averaging largest-fit ROIs over the nine Couinaud segments resulted in the narrowest limits of agreement (LOA) for liver PDFF and R2* measurements in both cohorts, suggesting clinicians and researchers should sample as much area of the liver as possible using multiple large ROIs.
Journal ArticleDOI
Diagnostic accuracy of CE-CT, MRI and FDG PET/CT for detecting colorectal cancer liver metastases in patients considered eligible for hepatic resection and/or local ablation
Kim Sivesgaard,Lars P. Larsen,Michael Sørensen,Stine Kramer,Sven Schlander,Nerijus Amanavicius,Arindam Bharadwaz,Dennis Tønner Nielsen,Frank Viborg Mortensen,Erik Morre Pedersen +9 more
TL;DR: MRI performed significantly better than both CE-CT and combined FDG-PET/CT for detection of CRLM in consecutive patients eligible for local treatment irrespective of prior chemotherapy or local treatment.
Journal ArticleDOI
Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease.
TL;DR: Several different emerging quantitative ultrasound-based approaches used for detection and quantification of hepatic steatosis in patients at risk for nonalcoholic fatty liver disease are reviewed.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.