Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Accuracies of Chemical Shift In/Opposed Phase and Chemical Shift Encoded Magnetic Resonance Imaging to Detect Intratumoral Fat in Hepatocellular Carcinoma
Kritisha Rajlawot,Ting Jiang,Jing Zhou,ChuRong Lin,Sichi Kuang,Jingbiao Chen,Yao Zhang,Hao Yang,Ying Deng,Bingjun He,Diego Hernando,Scott B. Reeder,Jin Wang +12 more
TL;DR: In this paper, the diagnostic accuracy of chemical shift encoded fat fraction at three different flip angles (FAs) using quantitative CSE-MRI with in-/opposed phase (IOP) imaging to evaluate intratumoral fat in HCC was compared.
Journal ArticleDOI
Comparing mono-exponential, bi-exponential, and stretched-exponential diffusion-weighted MR imaging for stratifying non-alcoholic fatty liver disease in a rabbit model
Chang Li,Chang Li,Ye Jing,Martin R. Prince,Yun Peng,Weiqiang Dou,Songan Shang,Jingtao Wu,Xianfu Luo +8 more
TL;DR: Stretched-exponential DWI with higher fitting efficiency performed, as well as bi-exponian DWI, better than mono-exp exponential DWI in the stratification of NAFLD severity.
Journal ArticleDOI
Proposed cut-off value of the intrahepatic lipid content for metabolically normal persons assessed by proton magnetic resonance spectroscopy in a Japanese population.
Fumiaki Matsubara,Fumiaki Matsubara,Yoshio Nagai,Yoshio Nagai,Hidekazu Tsukiyama,Hidekazu Tsukiyama,Hiroyuki Shimizu,Eigoro Yamanouchi,Teruaki Iwamoto,Yukiyoshi Sada,Hiroyuki Kato,Akio Ohta,Yasushi Tanaka +12 more
TL;DR: This study demonstrated a close association of IHL with features of MetS and identified IHL content cut-off values for metabolic normality in Japanese subjects.
Journal ArticleDOI
Prospective study of change in liver function and fat in patients with colorectal liver metastases undergoing preoperative chemotherapy: protocol for the CLiFF Study.
Kathryn L Parmar,Derek A O'Reilly,Juan W. Valle,M. Braun,Josephine H. Naish,Steve R. Williams,William Lloyd,Lee Malcomson,Katharine Cresswell,Colin Bamford,Andrew G Renehan +10 more
TL;DR: A novel test of liver function is used, measured by the liver maximum capacity (LiMAx) test, and liver fat is measured by advanced MRI using both MR spectroscopy and the modified Dixon method, in up to 35 patients undergoing preoperative chemotherapy for CLM.
Journal ArticleDOI
3.0T 1H magnetic resonance spectroscopy for assessment of steatosis in patients with chronic hepatitis C
Qian Zhang,Hui-Mao Zhang,Wenqian Qi,Yonggui Zhang,Ping Zhao,Jian Jiao,Jiangbin Wang,Chun-Yu Zhang +7 more
TL;DR: It is indicated that the (1)H MRS can be used as an indicator of steatosis in patients with chronic hepatitis C and is a noninvasive technique that can provide information on the effect of liver Steatosis on hepatic metabolic processes.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
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Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.