Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Diffüz Karaciğer Hastalıkları
Bengi Gurses,Mustafa Secil +1 more
TL;DR: Diffüz karaciğer hastalıkları (DKH) as discussed by the authors, farklı nedenlerle oluşabilen, KARACIğerde fokal formda olmayan değişiklikler meydana getiren geniş bir hastalÕk grubudur.
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Comparing magnetic resonance liver fat fraction measurements with histology in fibrosis: the difference between proton density fat fraction and tissue mass fat fraction.
Stephen Bawden,Caroline L. Hoad,Philip Kaye,Mary C. Stephenson,G E Dolman,Martin Lames,Emilie Wilkes,Andrew Austin,Indra Neil Guha,Susan T. Francis,Penny A. Gowland,Guruprasad P. Aithal +11 more
TL;DR: In this article , the authors investigated whether a tissue water content correction, as assessed by MRI relaxometry, could provide better agreement between MRI and visual estimates of fat fraction in fibrotic livers.
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Controlled attenuation parameter in the diagnosis of different liver steatosis groups in children with obesity
TL;DR: To investigate the utility of the controlled attenuation parameter (CAP), as measured by a liver elastography technique, in predicting varying degrees of liver steatosis in children with obesity, a large number of children are diagnosed with obesity.
Journal ArticleDOI
Response to Comment on Tang et al. Effects of Insulin Glargine and Liraglutide Therapy on Liver Fat as Measured by Magnetic Resonance in Patients With Type 2 Diabetes: A Randomized Trial. Diabetes Care 2015;38:1339-1346.
An Tang,Rémi Rabasa-Lhoret,Hélène Castel,Claire Wartelle-Bladou,Guillaume Gilbert,Guillaume Gilbert,Karine Massicotte-Tisluck,Gabriel Chartrand,Damien Olivié,Anne-Sophie Julien,Jacques A. de Guise,Gilles Soulez,Jean-Louis Chiasson +12 more
Abstract: Shan et al. (1) raise important points regarding treatment duration, sample size, mean values of magnetic resonance (MR)-based biomarkers, and severity of liver steatosis in our study (2).
The 12-week duration of our study was justified by the exploratory aim to compare two second-line injectable treatment alternatives on liver steatosis as measured by MR-based techniques. To acknowledge that the study duration was too short to address the long-term effects on liver steatosis, we preemptively stated in our discussion that “a longer study would have favored GLP-1 agonist therapy in terms of body weight loss and, possibly, a concomitant reduction in the liver fat fraction” …
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Morphological characterization of hepatic steatosis and Monte Carlo modeling of MRI signal for accurate quantification of fat fraction and relaxivity
Utsav Shrestha,Marie van der Merwe,Nirman Kumar,Eddie L. Jacobs,Sanjaya K. Satapathy,Cara E. Morin,Aaryani Tipirneni-Sajja,Aaryani Tipirneni-Sajja +7 more
TL;DR: In this paper, the authors proposed a method to generate realistic steatosis models from histology and synthesize MRI signal using Monte Carlo simulations to investigate the accuracy of single-and dual-R2 * models in quantifying FF and R2 * values.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
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Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
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Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
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Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.