Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Journal ArticleDOI
Feasibility of a three-step magnetic resonance imaging approach for the assessment of hepatic steatosis in an asymptomatic study population
Holger Hetterich,Christian Bayerl,Annette Peters,Margit Heier,Birgit Linkohr,Christa Meisinger,Sigrid Auweter,Stephan Kannengießer,Harald Kramer,Harald Kramer,Birgit Ertl-Wagner,Fabian Bamberg,Fabian Bamberg +12 more
TL;DR: Dual-echo Dixon can rapidly and reliably exclude hepatic steatosis without complex post-processing and can be implemented in routine abdominal MRI protocols, thus hepatic fat can be evaluated without relevant increase in scan time.
Journal ArticleDOI
Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis.
TL;DR: Results demonstrate the utility of quantitative MRI methods for treatment monitoring using a novel, noninvasive imaging-based biomarker of hepatic steatosis, and determine that longitudinal changes in MRI-derived PDFF was more sensitive to detection of changes in liver fat than biopsy.
Journal ArticleDOI
Fat fraction mapping using magnetic resonance imaging: insight into pathophysiology.
TL;DR: Methods for fat quantification are reviewed and their strengths and weaknesses are considered, before considering how they can be tailored to specific applications, particularly in the gastrointestinal and musculoskeletal systems.
Journal ArticleDOI
Fat and iron quantification in the liver: past, present, and future.
TL;DR: Standardized radiological metrics of fat and iron are introduced for numerical reporting of overload severity, which can be used toward objective diagnosis, grading, and longitudinal disease monitoring and serve an alternative or complimentary role to invasive liver biopsy.
Journal ArticleDOI
Assessment of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease by Using Quantitative US
Aiguo Han,Yingzhen N. Zhang,Andrew S. Boehringer,Vivian Montes,Michael P. Andre,John W. Erdman,Rohit Loomba,Mark A. Valasek,Claude B. Sirlin,William D. O'Brien +9 more
TL;DR: A multivariable quantitative US approach yielded excellent correlation with MRI proton density fat fraction for hepatic steatosis assessment in nonalcoholic fatty liver disease.
References
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David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
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Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
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Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
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Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
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