Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
More filters
Journal ArticleDOI
Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing.
Fabian Lohöfer,Georgios Kaissis,Christina Müller-Leisse,Daniela Franz,Christoph Katemann,Andreas Hock,Johannes M. Peeters,Ernst J. Rummeny,Dimitrios C. Karampinos,Rickmer Braren +9 more
TL;DR: CS+SENSE accelerates liver PDFF and T2*mapping while retaining the same quantitative values as an acquisition using only SENSE and reduces motion artifacts.
Journal ArticleDOI
Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease.
Eleni Rebelos,Patricia Iozzo,Maria Angela Guzzardi,Maurizia Rossana Brunetto,Ferruccio Bonino +4 more
TL;DR: In this paper, a review of the brain-gut-liver axis in the context of metabolic dysregulations associated with fatty liver, where insulin resistance has been assumed to play an important role, is presented.
Journal ArticleDOI
Alterations in the Liver Fat Fraction Features Examined by Magnetic Resonance Imaging Following Bariatric Surgery: a Self-Controlled Observational Study.
Mengyi Li,Di Cao,Yang Liu,Lan Jin,Na Zeng,Lixue Wang,Kaixin Zhao,Han Lv,Meng Zhang,Peng Zhang,Zhenghan Yang,Zhongtao Zhang +11 more
TL;DR: LFF decreased following bariatric surgery, which predicted C-NASH score changes after surgery, and for patients with a higher risk of NASH at baseline and lower preoperative body weight, the effects of surgery on score change value were noted.
Journal ArticleDOI
Development of new drugs for the treatment of nonalcoholic steatohepatitis.
Jie Ting Tang,Yi Min Mao +1 more
TL;DR: An overview of NASH drug pipelines and the challenges faced in conducting phases II and III clinical trials is provided and how to establish guidelines for study design and end‐points in complex clinical trials of anti‐NASH drugs is discussed.
Journal ArticleDOI
Bone Marrow Fat Measured by a Chemical Shift‐Encoded Sequence (IDEAL‐IQ) in Patients With and Without Metabolic Syndrome
TL;DR: The relationship between metabolic syndrome and bone marrow fat is unclear as discussed by the authors, however, it is known that metabolic syndrome increases the risk of chronic diseases such as cardiovascular disease and diabetes and also has an impact on bone mineral density.
References
More filters
Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.