Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Journal ArticleDOI
Serum Alanine Aminotransferase as a Biomarker of Treatment Response in Nonalcoholic Steatohepatitis
TL;DR: The authors reported that there was no significant difference in serum ALT between the baseline and the week-12 value between the treatment-arm and the placebo-arm, and concluded that ASP9831 although safe in a 12-week study did not improve liver disease in patients with biopsy-proven NASH.
Posted ContentDOI
Linking abdominal imaging traits to electronic health record phenotypes
Matthew T. MacLean,Qasim Jehangir,Marijana Vujkovic,Yi-An Ko,Harold Litt,Arijitt Borthakur,Hersh Segreiya,Mark A. Rosen,David A. Mankoff,Mitchell D. Schnall,Haochang Shou,Julio A. Chirinos,Scott M. Damrauer,Drew A. Torigian,Rotonya M. Carr,Daniel J. Rader,Walter R Witschey +16 more
TL;DR: A fully automated image curation and organ labeling technique using deep learning to identify liver, spleen, subcutaneous and visceral fat compartments in the abdomen and extract 12 quantitative imaging traits to NAFLD is built, demonstrating the power of automated image quantitative trait analyses applied to routine clinical imaging studies to fuel translational scientific discovery.
Book ChapterDOI
Liver, Biliary Tract, Pancreas, and Spleen
Mi Jung Lee,Myung Joon Kim +1 more
TL;DR: This chapter presents various imaging findings of the liver, biliary tract, pancreas, and spleen in children, including congenital anomalies, inflammatory or infectious diseases, metabolic or infiltrative diseases, and tumorous conditions.
Journal ArticleDOI
Albuminuria Is Associated with Hepatic Iron Load in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome.
Manuela Abbate,Sofía Montemayor,Catalina M. Mascaró,Miguel Casares,Cristina Gomez,Lucía Ugarriza,Silvia Tejada,Silvia Tejada,Itziar Abete,Itziar Abete,M. Angeles Zulet,M. Angeles Zulet,Antoni Sureda,Antoni Sureda,J. Alfredo Martínez,J. Alfredo Martínez,J. Alfredo Martínez,Josep A. Tur,Josep A. Tur +18 more
TL;DR: In this paper, the relationship between hepatic iron load and urine albumin-to-creatinine ratio (UACR) in patients with metabolic syndrome (MetS) and NAFLD was assessed.
Journal ArticleDOI
[11C]acetate PET as a tool for diagnosis of liver steatosis.
Marzieh Nejabat,Asha Leisser,Georgios Karanikas,Wolfgang Wadsak,Markus Mitterhauser,Marius Mayerhöfer,Christian Kienbacher,Michael Trauner,Marcus Hacker,Alexander Haug +9 more
TL;DR: It is shown for the first time that hepatic steatosis associates with increased [11C]acetate uptake PET, and seems promising for the assessment of liver Steatosis.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.