Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease
TL;DR: This article showed that first-degree relatives of probands with nonalcoholic fatty liver disease (NAFLD) cirrhosis have a high risk of advanced fibrosis, and they aimed to validate these findings using two independent cohorts from the US and Europe.
Journal ArticleDOI
Direct Comparison of Quantitative US versus Controlled Attenuation Parameter for Liver Fat Assessment Using MRI Proton Density Fat Fraction as the Reference Standard in Patients Suspected of Having NAFLD.
Ji-Yong Jung,Aiguo Han,Egbert Madamba,Ricki Bettencourt,R. Loomba,Andrew S. Boehringer,Michael P. Andre,John W. Erdman,William D O'brien,Kathryn J. Fowler,Claude B. Sirlin,Rohit Loomba +11 more
TL;DR: The quantitative US fat fraction estimator is more accurate than the controlled attenuation parameter in the diagnosis of hepatic steatosis in patients with or suspected of having nonalcoholic fatty liver disease.
Journal ArticleDOI
Magnetic Resonance Imaging-Proton Density Fat Fraction vs. Transient Elastography-Controlled Attenuation Parameter in Diagnosing Non-alcoholic Fatty Liver Disease in Children and Adolescents: A Meta-Analysis of Diagnostic Accuracy
TL;DR: Both MRI-PDFF and TE-CAP are highly accurate non-invasive methods to grade the hepatic steatosis in children and adolescents with NAFLD.
Journal ArticleDOI
Agreement between region-of-interest- and parametric map-based hepatic proton density fat fraction estimation in adults with chronic liver disease
Paul Manning,Gavin Hamilton,Kang Wang,Chulhyun Park,Jonathan Hooker,Tanya Wolfson,Anthony Gamst,William Haufe,Alex N. Schlein,Michael S. Middleton,Claude B. Sirlin +10 more
TL;DR: Agreement between ROI- and parametric map-based PDFF estimation is excellent over a wide range of imaging and analysis conditions.
Journal ArticleDOI
Imaging Evaluation of Living Liver Donor Candidates: Techniques, Protocols, and Anatomy
Amir A. Borhani,Khaled M. Elsayes,Roberta Catania,Avinash Kambadakone,Alessandro Furlan,Andrea S. Kierans,Amita Kamath,Carla Harmath,Natally Horvat,Abhinav Humar,Ania Z. Kielar +10 more
TL;DR: Radiologic evaluation of living liver donor candidates is an integral component of their preoperative workup to ensure their eligibility for hepatectomy and to provide a road map for the surgery as mentioned in this paper.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.