Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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How bariatric surgery affects liver volume and fat density in NAFLD patients.
Ran B. Luo,Toshiaki Suzuki,Jonathan Hooker,Yesenia Covarrubias,Alexandra Schlein,Shanglei Liu,Jeffrey B. Schwimmer,Scott B. Reeder,Luke M. Funk,Jacob A. Greenberg,Guilherme M. Campos,Bryan J. Sandler,Santiago Horgan,Claude B. Sirlin,Garth R. Jacobsen +14 more
TL;DR: Patients with NAFLD undergoing bariatric surgery can expect significant decreases in liver volume and hepatic steatosis at 6 months, with 83.7% of patients achieving resolution of steatotic.
Journal ArticleDOI
Quantification of the fat fraction in the liver using dual-energy computed tomography and multimaterial decomposition
TL;DR: Quantification of the HFF using postcontrast DECT with MMD was feasible and showed comparable sensitivity and specificity to the precontrast SECT for the detection of hepatic steatosis.
Journal ArticleDOI
Non-alcoholic fatty liver disease: need for a balanced nutritional source.
TL;DR: Understanding the specific interaction between nutrients and dietary needs in NAFLD and maintaining this balance through either a diet or a nutritional product thus becomes extremely important in providing a more realistic and feasible alternative to treatNAFLD.
Journal ArticleDOI
MRI-determined liver proton density fat fraction, with MRS validation: Comparison of regions of interest sampling methods in patients with type 2 diabetes.
Kim-Nhien Vu,Guillaume Gilbert,Guillaume Gilbert,Marianne Chalut,Miguel Chagnon,Gabriel Chartrand,An Tang +6 more
TL;DR: To assess the agreement between published magnetic resonance imaging (MRI)‐based regions of interest (ROI) sampling methods using liver mean proton density fat fraction (PDFF) as the reference standard, an apples-to- apples comparison study is conducted.
Journal ArticleDOI
Pediatric Non-Alcoholic Fatty Liver Disease.
TL;DR: The rapidly increasing prevalence of childhood obesity and its associated co-morbidities such as hypertriglyceridemia, hyper-insulinemia, hypertension, early atherosclerosis, metabolic syndrome, and non-alcoholic fatty liver disease are major public health concerns in many countries and should be closely monitored over time.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.