Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Important food sources of fructose-containing sugars and adiposity: A systematic review and meta-analysis of controlled feeding trials
TL;DR: In this paper , the effect of food sources of fructose-containing sugars by energy control on adiposity was investigated in a systematic review and meta-analysis, MEDLINE, Embase, and Cochrane Library were searched through April 2022 for controlled trials ≥2 wk.
Dissertation
Cuantificación y monitorización del hígado graso no alcohólico mediante resonancia magnética
TL;DR: La RM multieco puede ser un metodo diagnostico incruento that permita cuantificar y monitorizar de forma precisa the grasa intrahepatica, i.e. el contenido hepatico de lipidos.
Journal ArticleDOI
Prospective comparison of longitudinal change in hepatic proton density fat fraction (PDFF) estimated by magnitude-based MRI (MRI-M) and complex-based MRI (MRI-C)
Adrija Mamidipalli,Kathryn J. Fowler,Gavin Hamilton,Tanya Wolfson,Yesenia Covarrubias,Calvin Andrew Tran,Soudabeh Fazeli,Curtis N. Wiens,Alan B. McMillan,Nathan S. Artz,Luke M. Funk,Guilherme M. Campos,Jacob A. Greenberg,Anthony Gamst,Michael S. Middleton,Jeffrey B. Schwimmer,Scott B. Reeder,Claude B. Sirlin +17 more
TL;DR: The findings support the use of either MRI technique (MRI-M or MRI-C) for clinical care or by individual sites or for multi-center trials that include PDFF change as an endpoint in adults with severe obesity and biopsy- proven NAFLD enrolled in a weight loss surgery program.
Patent
Method and system for determining a corrected value of magnetic resonance relaxometry data of a subject's visceral tissue for extracellular fluid based on a normal iron content for the visceral tissue
TL;DR: In this paper, the authors provide systems and methods which may assist in evaluating liver fibrosis/inflammation in the presence of elevated iron using magnetic resonance relaxometry, which can include a measurement of relaxometry data of a subject's liver for extracellular fluid, preferably using a magnetic resonance imaging (MRI) device.
Journal ArticleDOI
Effect of Gd-DOTA on fat quantification in skeletal muscle using two-point Dixon technique - preliminary data.
Lukas Filli,Erika J. Ulbrich,Roman Guggenberger,Andreas Boss,Michael A. Fischer,Filippo Del Grande,Britta Maurer,Gustav Andreisek +7 more
TL;DR: Gd-DOTA does not significantly influence FSF quantification in skeletal muscle based on the two-point Dixon technique at 3T, and almost equivalent FSF estimation between pre- and post-contrast measurements was indicated.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.