Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Journal ArticleDOI
Abdominal magnetic resonance imaging assessment and quantification of pancreatic and liver adipose tissues in obesity before and after laparoscopic sleeve gastrectomy
TL;DR: In this paper , the changes of liver and pancreas fat fraction after laparoscopic sleeve gastrectomy (LSG) were investigated by magnetic resonance imaging (MRI) in morbid obesity patients.
Book ChapterDOI
Magnetic Resonance Imaging of the Liver: Technical Considerations
TL;DR: In this paper, the authors review the protocols for liver imaging using standard technical specifications able to provide reproducible image quality, and to review advanced applications encompassing quantification issues, allowing therapeutical monitoring and disease follow-up.
Journal ArticleDOI
The effect of hepatic steatosis on liver volume determined by proton density fat fraction and deep learning-measured liver volume.
Ji Young Choi,Seung Soo Lee,Na Young Kim,Hyojung Park,Yu Sub Sung,Yedaun Lee,Jeeseok Yoon,Heung-Il Suk +7 more
accuracy of M r imaging- estimated Proton Density Fat Fraction for classification of Dichotomized histologic s teatosis grades in nonalcoholic
An Tang,Ajinkya Desai,Gavin Hamilton,Anthony Gamst,Jessica Lam,Jonathan C. Hooker,Brandon Ang,Michael S. Middleton,Michael R. Peterson,Rohit Loomba,Claude B. Sirlin +10 more
Journal ArticleDOI
Magnetic resonance imaging for the assessment of pathological hepatic findings in nonalcoholic fatty liver disease
TL;DR: In this article , the authors discuss nonalcoholic fatty liver disease and non-alcoholic steatohepatitis with magnetic resonance imaging (MRI) and nonfunctional liver disease.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.