Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Journal ArticleDOI
Non‐alcoholic steatohepatitis, but not simple steatosis, disturbs the functional homogeneity of the liver – a human galactose positron emission tomography study
Peter Lykke Eriksen,Karen Louise Thomsen,Lars P. Larsen,Henning Grønbæk,Hendrik Vilstrup,Michael Sørensen +5 more
TL;DR: The disease severity of non‐alcoholic fatty liver disease (NAFLD) and the distinction between simple steatosis and non-alcoholic steatohepatitis (NASH) are based on the pathohistological presence of steatotic changes, but little is known about the relation between structural changes and the function of the afflicted liver.
Journal ArticleDOI
Effect of gadolinium on hepatic fat quantification using multi-echo reconstruction technique with T2* correction and estimation
TL;DR: Although under the impact of an increased R2* in liver and spleen post-contrast, the investigational sequence can still obtain stable fat quantification and can be integrated into tri-phase liver MRI without adding scan time.
Journal ArticleDOI
Effect of intravenous gadoxetate disodium and flip angle on hepatic proton density fat fraction estimation with six-echo, gradient-recalled-echo, magnitude-based MR imaging at 3T.
Charlie C. Park,Gavin Hamilton,Ajinkya Desai,Kevin A Zand,Tanya Wolfson,Jonathan Hooker,Eduardo A. C. Costa,Elhamy Heba,Lisa Clark,Anthony Gamst,Rohit Loomba,Michael S. Middleton,Claude B. Sirlin +12 more
TL;DR: In patients undergoing Gx-enhanced MR exams, PDFF estimation accuracy of MRI-M can be improved by using high-FA on post-contrast images.
Journal ArticleDOI
Screening HIV patients at risk for NAFLD using MRI-PDFF and transient elastography: a European multicenter prospective study.
Maud Lemoine,Lambert Assoumou,Pierre-Marie Girard,Marc-Antoine Valantin,Christine Katlama,Stéphane De Wit,Pauline Campa,Hayette Rougier,Jean-Luc Meynard,Coca Necsoi,A. Huefner,Jan Van Luzen,Julian Schulze zur Wiesch,Jean-Philippe Bastard,Soraya Fellahi,Stefan Mauss,Metodi V. Stankov,Axel Baumgarten,Gerrit Post,Lawrence Serfaty,Vlad Ratziu,Yves Menu,Jerome Schlue,Pierre Bedossa,Jacqueline Capeau,Dominique Costagliola,Georg Behrens,Patrick Ingiliz +27 more
TL;DR: In this paper , the prevalence and associated factors of liver steatosis and advanced fibrosis (AF) in HIV-monoinfected patients at risk of NAFLD were assessed.
Journal ArticleDOI
Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study
Catalina M. Mascaró,Cristina Bouzas,Sofía Montemayor,M. Casares,Cristina Gómez,Lucía Ugarriza,Pere A. Borras,José Alfredo Martínez,Josep A. Tur +8 more
TL;DR: NAFLD patients with high PA showed more positive relationship on MetS parameters and liver profile (ALT, GGT, IFC-NMR) than subjects with low PA, but not for AST.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
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Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.