Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TLDR
MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.Abstract:
MR imaging with proton density fat fraction (PDFF) permitted high overall accuracy with moderate sensitivity and high specificity for classification of dichotomized steatosis grade, and these results support the conduct of further studies to help validate MR imaging–PDFF as a biomarker of hepatic steatosis in nonalcoholic fatty liver disease.read more
Citations
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Functional MR imaging of the liver
TL;DR: In this article, the basic principles of functional MRI of the liver and discusses the importance in a clinical context, and the sequelae of diffuse liver diseases, such as decreased liver functional reserve or portal hypertension, can also be detected and quantified by modern MRI methods.
Dissertation
The role of MRI in stratifying and evaluating chronic liver disease
TL;DR: It is demonstrated that multiparametric MRI can stage hepatic fibrosis in an unselected cohort with performance comparable to existing non-invasive fibrosis markers.
Journal ArticleDOI
Effects Of Fatty Liver On The Size And Composition Of High‐Density Lipoprotein Cholesterol Subpopulations In Adolescents With Type 2 Diabetes Mellitus
José Antonio Orozco Morales,Aída Xochitl Medina Urrutia,Margarita Torres Tamayo,Esteban Jorge Galarza,Juan Reyes Barrera,Pilar Dies Suarez,Juan Gabriel Juárez Rojas,Patricia Medina-Bravo +7 more
TL;DR: Type 2 diabetes mellitus is an emerging disease in the pediatric population and the association between T2DM and non‐alcoholic fatty liver disease (NAFLD) has been described.
Journal ArticleDOI
Brazilian Society of Hepatology and Brazilian College of Radiology practice guidance for the use of elastography in liver diseases.
Ana Carolina Cardoso,Cristiane A. Villela-Nogueira,C. Figueiredo-Mendes,Hilton Leão Filho,Rogério A. P. Silva,Cristiane Valle Tovo,Hugo Perazzo,Antonio Carlos Matteoni,Roberto J. Carvalho-Filho,Paulo Lisboa Bittencourt +9 more
TL;DR: In 2019, the Brazilian Society of Hepatology (SBH) and the Brazilian College of Radiology (CBR) sponsored a single-topic meeting on liver fibrosis and steatosis as discussed by the authors.
Journal ArticleDOI
Diagnostic Accuracy and Optimal Cut-off of Controlled Attenuation Parameter for the Detection of Hepatic Steatosis in Indian Population
Mohammad Shafi Kuchay,Narendra S. Choudhary,Deepak Sharma,Sonal Krishan,Sunil Kumar Mishra,Jasjeet Singh Wasir,Manish K. Singh,Neeraj Saraf,Swapnil Dhampalwar,Randhir Sud +9 more
TL;DR: This book aims to provide a history of endocrinology and diabetes in India and some of the cases studied up to and including the year of Jawaharlal Nehru's death.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Sampling variability of liver biopsy in nonalcoholic fatty liver disease.
Vlad Ratziu,Frédéric Charlotte,A. Heurtier,Sophie Gombert,Philippe Giral,Eric Bruckert,André Grimaldi,Frédérique Capron,Thierry Poynard +8 more
TL;DR: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies.