Oscillatory Expression of Hes1, p53, and NF-κB Driven by Transcriptional Time Delays
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TLDR
Results provide direct evidence that transcriptional delays can drive oscillatory gene activity and highlight the importance of considering delays when analyzing genetic regulatory networks, particularly in processes such as developmental pattern formation, where short half-lives and feedback inhibition are common.About:
This article is published in Current Biology.The article was published on 2003-08-19 and is currently open access. It has received 694 citations till now. The article focuses on the topics: HES1 & Nuclear protein.read more
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Stochasticity in gene expression: from theories to phenotypes
TL;DR: Stochasticity in gene expression can provide the flexibility needed by cells to adapt to fluctuating environments or respond to sudden stresses, and a mechanism by which population heterogeneity can be established during cellular differentiation and development.
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Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
David E. Nelson,Adaoha E. C. Ihekwaba,M Elliott,James R. Johnson,C. A. Gibney,B. E. Foreman,Glyn Nelson,Violaine Sée,Caroline A. Horton,David G. Spiller,Steven W. Edwards,H. P. McDowell,John Unitt,Elaine Sullivan,Rachel L. Grimley,Neil Benson,David S. Broomhead,Douglas B. Kell,Michael R. H. White +18 more
TL;DR: Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription.
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Design principles of biochemical oscillators.
Bela Novak,John J. Tyson +1 more
TL;DR: Four general requirements for biochemical oscillations are discussed: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactions.
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Autoinhibition with Transcriptional Delay: A Simple Mechanism for the Zebrafish Somitogenesis Oscillator
TL;DR: It is shown by mathematical simulation that direct autorepression of her1 and her7 by their own protein products provides a mechanism for the intracellular oscillator, and Such Notch-mediated synchronous oscillations are predicted even in the absence of direct her1/her7 autoregulation.
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Oscillations and variability in the p53 system
Naama Geva-Zatorsky,Nitzan Rosenfeld,Shalev Itzkovitz,Ron Milo,Alex Sigal,Erez Dekel,Talia Yarnitzky,Yuvalal Liron,Paz Polak,Galit Lahav,Uri Alon +10 more
TL;DR: A view of the extensive variability of the behavior of a protein circuit in living human cells, both from cell to cell and in the same cell over time is provided.
References
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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Michael Karin,Yinon Ben-Neriah +1 more
TL;DR: Recent progress has been made in understanding the details of the signaling pathways that regulate NF-kappaB activity, particularly those responding to the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1.
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The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
TL;DR: A computational model is presented that describes the temporal control of NF-κB activation by the coordinated degradation and synthesis of IκB proteins and demonstrates that IπκBα is responsible for strong negative feedback that allows for a fast turn-off of the NF-σB response.
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Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell
TL;DR: This work has demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms and shed light on the design principles of biological control systems and make predictions that have been verified experimentally.
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The p53 pathway
Carol Prives,Peter A. Hall +1 more
TL;DR: Progress in the analysis of signalling to p53 including phosphorylation cascades, and interactions with proteins such as mdm2 and ARF are highlighted, and the plethora of protein–protein interactions is discussed, as are the strategies for defining downstream targets of p53.
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Oscillatory behavior in enzymatic control processes
TL;DR: It is suggested that spontaneous oscillatory behavior in an organism's control processes constitutes the dynamic basis of rhythmic behavior patterns in plant and animal physiology.