Parkinson's disease in relation to pesticide exposure and nuclear encoded mitochondrial complex I gene variants.
TLDR
It is concluded that inherited variation in mitochondrial complex I genes and pesticide exposure together modulate risk for PD.Abstract:
Parkinson's disease (PD) is a common age-related neurodegenerative disorder thought to result from the integrated effects of genetic background and exposure to neuronal toxins. Certain individual nuclear-encoded mitochondrial complex I gene polymorphisms were found to be associated with ∼2-fold risk variation in an Australian case-control sample. We further characterized this sample of 306 cases and 321 controls to determine the mutual information contained in the 22 SNPs and, additionally, level of pesticide exposure: five distinct risk sets were identified using grade-of-membership analysis. Of these, one was robust to pesticide exposure (I), three were vulnerable (II, III, IV), and another (V) denoted low risk for unexposed persons. Risk for individual subjects varied g16-fold according to level of membership in the vulnerable groups. We conclude that inherited variation in mitochondrial complex I genes and pesticide exposure together modulate risk for PD.read more
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Drug Delivery Systems: Advanced Technologies Potentially Applicable In Personalised Treatment
Jorge F. J. Coelho,Paula Ferreira,Paula Ferreira,Patrícia Alves,Rosemeyre A. Cordeiro,Ana Catarina R.G. Fonseca,Joana R. Góis,Maria H. Gil +7 more
TL;DR: General concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes) are described.
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