Patterns of growth among children who later develop type 2 diabetes or its risk factors
TLDR
Low weight gain during infancy increases the risk of IGT and type 2 diabetes and the effect is greater in people who had low birthweight, which may be the most critical period for growth, in relation to development of glucose intolerance.Abstract:
Aims/hypothesis
We studied fetal and childhood growth patterns that are associated with IGT and type 2 diabetes in adult life.read more
Citations
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Journal ArticleDOI
Associations of linear growth and relative weight gain during early life with adult health and human capital in countries of low and middle income: findings from five birth cohort studies
Linda S. Adair,Caroline H.D. Fall,Clive Osmond,Aryeh D. Stein,Reynaldo Martorell,Manuel Ramirez-Zea,Harshpal Singh Sachdev,Darren Dahly,Isabelita Bas,Shane A. Norris,Lisa K. Micklesfield,Pedro C. Hallal,Cesar G. Victora +12 more
TL;DR: Interventions in countries of low and middle income to increase birthweight and linear growth during the first 2 years of life are likely to result in substantial gains in height and schooling and give some protection from adult chronic disease risk factors, with few adverse trade-offs.
Journal ArticleDOI
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
Valeriya Lyssenko,Cecilia Nagorny,Michael R. Erdos,Nils Wierup,Anna Jonsson,Peter Spégel,Marco Bugliani,Richa Saxena,Richa Saxena,Malin Fex,Nicolo Pulizzi,Bo Isomaa,Tiinamaija Tuomi,Peter M. Nilsson,Johanna Kuusisto,Jaakko Tuomilehto,Michael Boehnke,David Altshuler,David Altshuler,Frank Sundler,Johan G. Eriksson,Anne U. Jackson,Markku Laakso,Piero Marchetti,Richard M. Watanabe,Hindrik Mulder,Leif Groop,Leif Groop +27 more
TL;DR: In this paper, the authors showed that the risk genotype of this SNP predicts future type 2 diabetes (T2D) in two large prospective studies, and the risk was associated with impairment of early insulin response to both oral and intravenous glucose and with faster deterioration of insulin secretion over time.
Journal ArticleDOI
Glucose Regulation in Young Adults with Very Low Birth Weight
Petteri Hovi,Sture Andersson,Johan G. Eriksson,Anna-Liisa Järvenpää,Sonja Strang-Karlsson,Outi Mäkitie,Eero Kajantie +6 more
TL;DR: Young adults with a very low birth weight have higher indexes of insulin resistance and glucose intolerance and higher blood pressure than those born at term and adjustment for the lower lean body mass in the very-low-birth-weight subjects did not attenuate these relationships.
Journal ArticleDOI
Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood
TL;DR: Rapid weight gain during the first 3 months of life resulted in a higher percentage of body fat, more central adiposity, and reduced insulin sensitivity in early adulthood than when slower weight gain occurred during the entire first year.
Journal ArticleDOI
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Raymond K. Walters,Raymond K. Walters,Renato Polimanti,Emma C. Johnson,Jeanette N. McClintick,Mark Adams,Amy E. Adkins,Fazil Aliev,Silviu-Alin Bacanu,Anthony Batzler,Sarah Bertelsen,Joanna M. Biernacka,Tim B. Bigdeli,Li-Shiun Chen,Toni-Kim Clarke,Yi-Ling Chou,Franziska Degenhardt,Anna R. Docherty,Alexis C. Edwards,Pierre Fontanillas,Jerome C. Foo,Louis Fox,Josef Frank,Ina Giegling,Scott Gordon,Laura M. Hack,Annette M. Hartmann,Sarah M. Hartz,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Colin A. Hodgkinson,Per Hoffmann,Per Hoffmann,Jouke-Jan Hottenga,Martin A. Kennedy,Mervi Alanne-Kinnunen,Bettina Konte,Jari Lahti,Marius Lahti-Pulkkinen,Dongbing Lai,Lannie Ligthart,Anu Loukola,Brion S. Maher,Hamdi Mbarek,Andrew M. McIntosh,Matthew B. McQueen,Jacquelyn L. Meyers,Yuri Milaneschi,Teemu Palviainen,John F. Pearson,Roseann E. Peterson,Samuli Ripatti,Euijung Ryu,Nancy L. Saccone,Jessica E. Salvatore,Sandra Sanchez-Roige,Melanie L. Schwandt,Richard Sherva,Fabian Streit,Jana Strohmaier,Nathaniel Thomas,Jen-Chyong Wang,Bradley T. Webb,Robbee Wedow,Leah Wetherill,Amanda G. Wills,Jason D. Boardman,Danfeng Chen,Doo Sup Choi,William E. Copeland,Robert Culverhouse,Norbert Dahmen,Louisa Degenhardt,Benjamin W. Domingue,Sarah L. Elson,Mark A. Frye,Wolfgang Gäbel,Caroline Hayward,Marcus Ising,Margaret Keyes,Falk Kiefer,John Kramer,Samuel Kuperman,Susanne Lucae,Michael T. Lynskey,Wolfgang Maier,Karl Mann,Satu Männistö,Bertram Müller-Myhsok,Alison D. Murray,John I. Nurnberger,Aarno Palotie,Ulrich W. Preuss,Katri Räikkönen,Maureen Reynolds,Monika Ridinger,Norbert Scherbaum,Marc A. Schuckit,Michael Soyka,Michael Soyka,Jens Treutlein,Stephanie H. Witt,Norbert Wodarz,Peter Zill,Daniel E. Adkins,Joseph M. Boden,Dorret I. Boomsma,Laura J. Bierut,Sandra A. Brown,Kathleen K. Bucholz,Sven Cichon,E. Jane Costello,Harriet de Wit,Nancy Diazgranados,Danielle M. Dick,Johan G. Eriksson,Lindsay A. Farrer,Tatiana Foroud,Nathan A. Gillespie,Alison Goate,David Goldman,Richard A. Grucza,Dana B. Hancock,Kathleen Mullan Harris,Andrew C. Heath,Victor Hesselbrock,John K. Hewitt,Christian J. Hopfer,John Horwood,William G. Iacono,Eric O. Johnson,Jaakko Kaprio,Victor M. Karpyak,Kenneth S. Kendler,Henry R. Kranzler,Kenneth Krauter,Paul Lichtenstein,Penelope A. Lind,Matt McGue,James MacKillop,Pamela A. F. Madden,Hermine H. Maes,Patrik K. E. Magnusson,Nicholas G. Martin,Sarah E. Medland,Grant W. Montgomery,Elliot C. Nelson,Markus M. Nöthen,Abraham A. Palmer,Nancy L. Pedersen,Brenda W. J. H. Penninx,Bernice Porjesz,John P. Rice,Marcella Rietschel,Brien P. Riley,Richard J. Rose,Dan Rujescu,Pei-Hong Shen,Judy L. Silberg,Michael C. Stallings,Ralph E. Tarter,Michael M. Vanyukov,Scott I. Vrieze,Tamara L. Wall,John Whitfield,Hongyu Zhao,Benjamin M. Neale,Benjamin M. Neale,Joel Gelernter,Howard J. Edenberg,Arpana Agrawal +171 more
TL;DR: The largest genome-wide association study to date of DSM-IV-diagnosed AD found loci associated with AD and characterized the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.
References
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Journal ArticleDOI
Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Book
Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
Journal ArticleDOI
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
Journal ArticleDOI
Fetal and infant growth and impaired glucose tolerance at age 64.
C. N. Hales,David J.P. Barker,Penelope M.S. Clark,Lorna Cox,Caroline H.D. Fall,Clive Osmond,P D Winter +6 more
TL;DR: Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
Journal ArticleDOI
Trajectories of growth among children who have coronary events as adults.
TL;DR: On average, adults who had a coronary event had been small at birth and thin at two years of age and thereafter put on weight rapidly and was associated with insulin resistance in later life.