Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo
Nuno Guimarães-Camboa,Nuno Guimarães-Camboa,Paola Cattaneo,Yunfu Sun,Thomas Moore-Morris,Yusu Gu,Nancy D. Dalton,Edward Rockenstein,Eliezer Masliah,Kirk L. Peterson,William B. Stallcup,Ju Chen,Sylvia M. Evans +12 more
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TLDR
It is shown that the transcription factor Tbx18 selectively marks pericytes and vascular smooth muscle cells in multiple organs of adult mouse and suggests that the plasticity observed in vitro or following transplantation in vivo arises from artificial cell manipulations ex vivo.About:
This article is published in Cell Stem Cell.The article was published on 2017-03-02 and is currently open access. It has received 373 citations till now. The article focuses on the topics: Mural cell & Stromal cell.read more
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A molecular atlas of cell types and zonation in the brain vasculature
Michael Vanlandewijck,Michael Vanlandewijck,Liqun He,Maarj A. Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +20 more
TL;DR: The transcriptional basis of the gradual phenotypic change along the arteriovenous axis is uncovered and unexpected cell type differences are revealed: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells.
Journal ArticleDOI
Mesenchymal stem cell perspective: cell biology to clinical progress
Mark F. Pittenger,Dennis E. Discher,Bruno Péault,Donald G. Phinney,Joshua M. Hare,Arnold I. Caplan +5 more
TL;DR: The expansive and growing field of MSC research is teaching us basic human cell biology as well as how to use this type of cell for cellular therapy in a variety of clinical settings, and while much promise is evident, careful new work is still needed.
Journal ArticleDOI
Mesenchymal Stem Cells: Time to Change the Name!
TL;DR: The name of MSCs should be changed to Medicinal Signaling Cells to more accurately reflect the fact that these cells home in on sites of injury or disease and secrete bioactive factors that are immunomodulatory and trophic (regenerative) meaning thatThese cells make therapeutic drugs in situ that are medicinal.
Journal ArticleDOI
The Biology of Regeneration Failure and Success After Spinal Cord Injury.
TL;DR: The perineuronal net and how chondroitin sulfate proteoglycans deposited in both the glial scar and net impede axonal outgrowth at the level of the growth cone are discussed.
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Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature.
Sowmya Viswanathan,Yufang Shi,Yufang Shi,Jacques Galipeau,Mauro Krampera,Katarina LeBlanc,Ivan Martin,Jan A. Nolta,Donald G. Phinney,Luc Sensebé +9 more
TL;DR: The ISCT MSC committee continues to support the use of the acronym "MSCs" but recommends this be supplemented by tissue-source origin of the cells, which would highlight tissue-specific properties.
References
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Linda Madisen,Theresa A. Zwingman,Susan M. Sunkin,Seung Wook Oh,Hatim A. Zariwala,Hong Gu,Lydia Ng,Richard D. Palmiter,Michael Hawrylycz,Allan R. Jones,Ed S. Lein,Hongkui Zeng +11 more
TL;DR: A set of Cre reporter mice with strong, ubiquitous expression of fluorescent proteins of different spectra is generated and enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
TL;DR: Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
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Regeneration beyond the glial scar
Jerry Silver,Jared H. Miller +1 more
TL;DR: Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure.
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Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
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Socializing with the Neighbors: Stem Cells and Their Niche
TL;DR: This review, which examines adult stem cell niches and their impact on stem cell biology, highlights the importance of understanding how stem cells interact with their microenvironment to establish and maintain their properties.
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