Journal ArticleDOI
Phylogenetic Perspectives in Innate Immunity
Reads0
Chats0
TLDR
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.Abstract:
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.read more
Citations
More filters
Journal ArticleDOI
Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway
TL;DR: The results indicated that arctigenin exerted its anti-inflammatory effect by inhibiting ROS-dependent STAT signaling through its antioxidant activity and inhibits iNOS expression via suppressing JAK-STAT signaling pathway in macrophages.
Journal ArticleDOI
Specific Recognition of Leishmania major Poly-β-galactosyl Epitopes by Galectin-9 POSSIBLE IMPLICATION OF GALECTIN-9 IN INTERACTION BETWEEN L. MAJOR AND HOST CELLS
Isabelle Pelletier,Tomomi Hashidate,Tadasu Urashima,Nozomu Nishi,Takanori Nakamura,Masamitsu Futai,Yoichiro Arata,Ken-ichi Kasai,Mitsuomi Hirashima,Jun Hirabayashi,Sachiko Sato +10 more
TL;DR: Frontal affinity analysis with different lengths of poly-beta-galactosyllactose revealed that the galectin-9 affinity for polygalactose was enhanced in proportion to the number of Galbeta1-3 units present, suggesting distinctive roles for the galECTins in the L. major-specific development of leishmaniasis in the host.
Journal ArticleDOI
The novel antimicrobial peptide β3-defensin is produced by the amnion: A possible role of the fetal membranes in innate immunity of the amniotic cavity
Irina A. Buhimschi,Maher Jabr,Catalin S. Buhimschi,Anelia P. Petkova,Carl P. Weiner,Ghassan M. Saed +5 more
TL;DR: The ability of amnion cells to produce antimicrobial peptides produced by skin and mucosal surfaces and are an integral part of the innate immune system has not been explored as discussed by the authors.
Journal ArticleDOI
The components of the Daphnia pulex immune system as revealed by complete genome sequencing.
TL;DR: A survey of the immune-related genome of D. pulex found that some immune pathways, in particular the TOLL pathway, are fairly well conserved between insects and Daphnia, while other elements could not be recovered from the genome sequence.
Journal ArticleDOI
Immune response of Anopheles gambiae to the early sporogonic stages of the human malaria parasite Plasmodium falciparum
TL;DR: It is found that P.falciparum ingestion triggers a midgut‐associated, as well as a systemic, response in the mosquito, with three genes, NOS, defensin and GNBP, being regulated by ingestion of gametocytes, the infectious stage of the parasite.
References
More filters
Journal ArticleDOI
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
TL;DR: CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS.
Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.