Journal ArticleDOI
Phylogenetic Perspectives in Innate Immunity
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TLDR
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.Abstract:
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.read more
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The worm has turned – microbial virulence modeled in Caenorhabditis elegans
TL;DR: The nematode Caenorhabditis elegans is emerging as a facile and economical model host for the study of evolutionarily conserved mechanisms of microbial pathogenesis and innate immunity and its potential to simultaneously explore the molecular genetic determinants of both pathogen virulence and host defense.
Journal ArticleDOI
A lipopolysaccharide- and beta-1,3-glucan-binding protein from hemocytes of the freshwater crayfish Pacifastacus leniusculus. Purification, characterization, and cDNA cloning.
TL;DR: The results suggest that the 36-kDa LGBP plays a role in the activation of the proPO activating system in crayfish and thus seems to play an important role inThe innate immune system of cray fish.
Journal ArticleDOI
Can we predict biological activity of antimicrobial peptides from their interactions with model phospholipid membranes
Niv Papo,Yechiel Shai +1 more
TL;DR: Model phospholipid membranes have been used to study the mode of action of antimicrobial peptides and it is demonstrated that peptides that act preferentially on bacteria are also able to interact with and permeate efficiently anionicospholipids, whereas peptide that lyse mammalian cells bind and permeates efficiently both acidic and zwitterionic phospholIPids membranes.
Journal ArticleDOI
The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima
Ariel D. Chipman,David E. K. Ferrier,Carlo Brena,Jiaxin Qu,Daniel S.T. Hughes,Reinhard Schröder,Montserrat Torres-Oliva,Nadia Znassi,Huaiyang Jiang,Francisca C. Almeida,Francisca C. Almeida,Claudio R. Alonso,Zivkos Apostolou,Zivkos Apostolou,Peshtewani K. Aqrawi,Wallace Arthur,Jennifer C. J. Barna,Kerstin P. Blankenburg,Daniela Brites,Daniela Brites,Salvador Capella-Gutierrez,Marcus Coyle,Peter K. Dearden,Louis Du Pasquier,Elizabeth J. Duncan,Dieter Ebert,Cornelius Eibner,Galina Erikson,Galina Erikson,Peter D. Evans,Cassandra G. Extavour,Liezl Francisco,Toni Gabaldón,Toni Gabaldón,William J. Gillis,Elizabeth A. Goodwin-Horn,Jack E. Green,Sam Griffiths-Jones,Cornelis J. P. Grimmelikhuijzen,Sai Gubbala,Roderic Guigó,Yi Han,Frank Hauser,Paul Havlak,Luke Hayden,Sophie Helbing,Michael Holder,Jerome H.L. Hui,Julia P. Hunn,Vera S. Hunnekuhl,LaRonda Jackson,Mehwish Javaid,Shalini N. Jhangiani,Francis M. Jiggins,Tamsin E. M. Jones,Tobias S. Kaiser,Divya Kalra,Nathan J. Kenny,Viktoriya Korchina,Christie Kovar,F. Bernhard Kraus,François Lapraz,Sandra L. Lee,Jie Lv,Christigale Mandapat,Gerard Manning,Marco Mariotti,Robert Mata,Tittu Mathew,Tobias Neumann,Tobias Neumann,Irene Newsham,Dinh Ngoc Ngo,Maria Ninova,Geoffrey Okwuonu,Fiona Ongeri,William J. Palmer,Shobha Patil,Pedro Patraquim,Christopher Pham,Ling-Ling Pu,Nicholas H. Putman,Catherine Rabouille,Olivia Mendivil Ramos,Adelaide C. Rhodes,Helen E. Robertson,Hugh M. Robertson,Matthew Ronshaugen,Julio Rozas,Nehad Saada,Alejandro Sánchez-Gracia,Steven E. Scherer,Andrew M. Schurko,Kenneth W. Siggens,DeNard Simmons,Anna Stief,Eckart Stolle,Maximilian J. Telford,Kristin Tessmar-Raible,Rebecca Thornton,Maurijn van der Zee,Arndt von Haeseler,Arndt von Haeseler,James M Williams,Judith H. Willis,Yuanqing Wu,Xiaoyan Zou,Daniel Lawson,Donna M. Muzny,Kim C. Worley,Richard A. Gibbs,Michael Akam,Stephen Richards +112 more
TL;DR: The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged, and concludes that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata.
Journal ArticleDOI
Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses
David H. Wyllie,Endre Kiss-Toth,Alberto Visintin,S. C. Smith,S. Boussouf,David M. Segal,Gordon W. Duff,Steven K. Dower +7 more
TL;DR: It is suggested that mammalian responsiveness to some bacterial products may be mediated by combinations of TLRs, suggesting a mechanism for diversifying the repertoire of Toll-mediated responses.
References
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Journal ArticleDOI
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
TL;DR: CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS.
Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.