Journal ArticleDOI
Phylogenetic Perspectives in Innate Immunity
Reads0
Chats0
TLDR
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.Abstract:
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.read more
Citations
More filters
Journal ArticleDOI
Outer membrane protein A (OmpA) from Shigella flexneri 2a: A promising subunit vaccine candidate
TL;DR: Outer membrane proteins A (OmpA) are among the most immunodominant antigens in the outer membrane of gram negative bacteria and possess many characteristics desired of a vaccine candidate, which offers a novel vista to develop vaccine against shigellosis.
Journal ArticleDOI
Antimicrobial peptide defensin: Identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases
TL;DR: Mice expressing human neutrophil α-defensin showed more severe lung injuries after the aspiration of acidic contents than did control mice, suggesting the significance of defensin in the pathogenesis or the worsening of chronic obstructive pulmonary diseases, sepsis and psoriasis.
Journal ArticleDOI
Characterization of a mannose-binding lectin from channel catfish (Ictalurus punctatus).
Hao Zhang,Eric Peatman,Hong Liu,Hong Liu,Donghong Niu,Tingting Feng,Huseyin Kucuktas,Geoff Waldbieser,Liqiao Chen,Zhanjiang Liu +9 more
TL;DR: While liver was the predominant source of mannose-binding lectin gene expression in healthy tissues, mann Nose-binding Lectin expression in spleen rose sharply following challenge with a Gram-negative bacterium.
Journal ArticleDOI
Modulation of the Activity of Secretory Phospholipase A2 by Antimicrobial Peptides
Hongxia Zhao,Paavo K.J. Kinnunen +1 more
TL;DR: Results indicate that concerted action of antimicrobial peptides and sPLA2 could improve the efficiency of the innate response to infections.
Journal ArticleDOI
The role of reactive oxygen species in Anopheles aquasalis response to Plasmodium vivax infection.
Ana C. Bahia,Jose Henrique M. Oliveira,Marina S. Kubota,Helena R. C. Araújo,José Bento Pereira Lima,Claudia María Ríos-Velásquez,Marcus V. G. Lacerda,Pedro L. Oliveira,Yara M. Traub-Cseko,Paulo F. P. Pimenta +9 more
TL;DR: It appears that P. vivax manipulates the mosquito detoxification system in order to allow its own development, which can be an indirect effect of fewer competitive bacteria present in the mosquito midgut caused by the increase of ROS after catalase silencing.
References
More filters
Journal ArticleDOI
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
TL;DR: CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS.
Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.