Journal ArticleDOI
Phylogenetic Perspectives in Innate Immunity
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TLDR
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.Abstract:
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.read more
Citations
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Journal ArticleDOI
Innate Immune Recognition
TL;DR: Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
Journal ArticleDOI
Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
Journal ArticleDOI
Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
Journal ArticleDOI
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Michael Karin,Yinon Ben-Neriah +1 more
TL;DR: Recent progress has been made in understanding the details of the signaling pathways that regulate NF-kappaB activity, particularly those responding to the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1.
Journal ArticleDOI
Toll-like receptors: critical proteins linking innate and acquired immunity.
TL;DR: Evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses.
References
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TL;DR: These findings suggest that, when extracellular holoBPI is bound via its N-terminal domain to Gram-negative bacteria, the C-terminals of BPI promotes bacterial attachment to neutrophils and monocytes, leading to phagocytosis.
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The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll
Elizabeth Eldon,Sandra Kooyer,D. D'evelyn,Molly Duman,Patrick Lawinger,Juan Botas,Hugo J. Bellen +6 more
TL;DR: Analysis of the expression of 18w in different mutant backgrounds shows that it is under control of segment polarity and homeotic genes, and the data suggest that the 18W protein participates in the developmental program specified by segmentation and homeosis as a cell adhesion or receptor molecule that facilitates cell movements.
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Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting
Shubha Govind,Ruth Steward +1 more
TL;DR: The maternal determinants of dorsoventral polarity of the Drosophila embryo are derived from somatic and germ-line components of the egg chamber and result in asymmetric expression of zygotic genes that ultimately specify cell fate.
Journal Article
Complete complementary DNA sequence of the third component of complement of lamprey. Implication for the evolution of thioester containing proteins.
M Nonaka,M Takahashi +1 more
TL;DR: The results suggest that the putative lamprey C3 retains a close similarity to the common ancestor of the mammalian C3 and C4, which appeared to have had a three-subunit chain structure.