Journal ArticleDOI
Phylogenetic Perspectives in Innate Immunity
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TLDR
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.Abstract:
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.read more
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PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages
Susana Nogueira Diniz,Regina Nomizo,Patrícia Silva Cisalpino,Mauro M. Teixeira,Gordon D. Brown,Alberto Mantovani,Siamon Gordon,Luiz F. L. Reis,Adriana Abalen Martins Dias +8 more
TL;DR: Evidence is provided for a role of PTX3 as an important component of the innate‐immune response and as part of the host mechanisms that control fungal recognition and phagocytosis.
Journal ArticleDOI
Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement.
Young Gerl Ma,Mi Yhang Cho,Mingyi Zhao,Ji Won Park,Misao Matsushita,Teizo Fujita,Bok Luel Lee +6 more
TL;DR: Results indicate that human PGN and 1,3-β-d-glucan recognition proteins function as complement-activating lectins.
Journal ArticleDOI
The Drosophila melanogaster Toll Pathway Participates in Resistance to Infection by the Gram-Negative Human Pathogen Pseudomonas aeruginosa
Gee W. Lau,Boyan C. Goumnerov,Cynthia L. Walendziewicz,Jennifer Hewitson,Wenzhong Xiao,Mahajan-Miklos Shalina,Ronald G. Tompkins,Lizabeth A. Perkins,Laurence G. Rahme +8 more
TL;DR: The finding that Dorsal activity is required to restrict P. aeruginosa infectivity in Drosophila provides direct in vivo evidence for DorsAL function in adult fly immunity.
Journal ArticleDOI
Biology of Toll receptors: lessons from insects and mammals
Jean-Luc Imler,Liangbiao Zheng +1 more
TL;DR: Comparison of the genomes of mouse and human and the fruitfly Drosophila and the mosquito Anopheles revealed that the four species possess a similar number of Toll receptors, but phylogenetic analyses indicate that the families of Toll receptor expanded independently in insects and mammals.
Journal ArticleDOI
Induction of a Peptide with Activity against a Broad Spectrum of Pathogens in the Aedes aegypti Salivary Gland, following Infection with Dengue Virus
Natthanej Luplertlop,Pornapat Surasombatpattana,Sirilaksana Patramool,Emilie Dumas,Ladawan Wasinpiyamongkol,Laure Saune,Rodolphe Hamel,Eric Bernard,Denis Sereno,Frédéric Thomas,Frédéric Thomas,David Piquemal,Hans Yssel,Laurence Briant,Dorothée Missé +14 more
TL;DR: The present study underscores not only the importance of DENV-induced cecropin in the innate immune response of Ae.
References
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Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.