Journal ArticleDOI
Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA
TLDR
Plasmid DNA can be very efficiently encapsulated, either in a free form or in combination with PVP and PVA, into PLA-PEG nanoparticles and depending on the processing conditions, these nanoparticles release plasmidDNA either very rapidly or in a controlled manner.About:
This article is published in Journal of Controlled Release.The article was published on 2001-07-10. It has received 337 citations till now. The article focuses on the topics: Drug carrier & Ethylene glycol.read more
Citations
More filters
Journal ArticleDOI
Polymer-based nanocapsules for drug delivery
TL;DR: A comparative analysis is given of the size, zeta-potential, dispersion pH, shell thickness, encapsulation efficiency, active substance release, stability and in vivo and in vitro pharmacological performances, which allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier.
Journal ArticleDOI
Biodegradable nanoparticles for drug delivery and targeting
Meredith Hans,Anthony M. Lowman +1 more
TL;DR: In this article, the authors explore the potential use of polymeric nanoparticles as carriers for a wide range of drugs for therapeutic applications, including cancer therapy and controlled delivery of vaccines.
Journal ArticleDOI
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
TL;DR: In this review the most important preparation methods are described, especially those that make use of natural polymers, andvantages and disadvantages will be presented so as to facilitate selection of an appropriate nanoencapsulation method according to a particular application.
Journal ArticleDOI
Design and Production of Nanoparticles Formulated From Nano-Emulsion Templates-A Review
TL;DR: A link between nano-emulsion formulation methods and nanoparticle generation is proposed, while at the same time bearing in mind the above-mentioned parameters for active molecule encapsulation.
Journal ArticleDOI
Methods for the preparation and manufacture of polymeric nanoparticles.
TL;DR: This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules and presents the most recent innovations and progresses obtained over the last decade.
References
More filters
Journal ArticleDOI
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Synthetic DNA delivery systems.
Dan Luo,Saltzman Wm +1 more
TL;DR: The ability to safely and efficiently transfer foreign DNA into cells is a fundamental goal in biotechnology and rapid advances have recently been made in understanding of mechanisms for DNA stability and transport within cells.
Journal ArticleDOI
Oral gene delivery with chitosan--DNA nanoparticles generates immunologic protection in a murine model of peanut allergy.
TL;DR: It is demonstrated that oral allergen-gene immunization with chitosan–DNA nanoparticles is effective in modulating murine anaphylactic responses, and its prophylactic utility in treating food allergy is indicated.
Journal ArticleDOI
Biologically erodable microspheres as potential oral drug delivery systems
Edith Mathiowitz,Jules S. Jacob,Yong S. Jong,Gerardo Carino,Donald E. Chickering,Pravin Chaturvedi,Camilla A. Santos,Kavita Vijayaraghavan,Sean Montgomery,Michael J Bassett,Craig N. Morrell +10 more
TL;DR: It is shown that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelia covering the lymphoid tissue of Peyer's patches.
Journal ArticleDOI
Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
TL;DR: A pH gradient is shown, with the most acidic environment at the center of the spheres and higher pH near the edges, which is characteristic of diffusion-controlled release of the acidicdegradation products.
Related Papers (5)
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more