Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
Managing Recurrent Metastatic Head and Neck Cancer
TL;DR: In this paper, local therapies including reirradiation and salvage surgery, either alone or in combination with systemic treatment, may be used for selected patients with R/M HNSCC.
Prognostic markers in head and neck carcinoma
TL;DR: The study aimed at determining the role of HPV, tobacco and alcohol in laryngeal carcinomas and HLA class II associations in head and neck tumors and the implications for survival and disease implications is conducted.
Journal ArticleDOI
HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
Simona Citro,Claudia Miccolo,Alessandro Medda,Lavinia Ghiani,Marta Tagliabue,Mohssen Ansarin,Susanna Chiocca +6 more
TL;DR: In this article , the role of the human papillomavirus (HPV) infection in the upregulation of SMAD4 was investigated in head and neck cancer (HNC) patients.
Journal ArticleDOI
HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
Simona Citro,Claudia Miccolo,Alessandro Medda,Lavinia Ghiani,Marta Tagliabue,Mohssen Ansarin,Susanna Chiocca +6 more
TL;DR: In this paper , the role of the human papillomavirus (HPV) infection in the upregulation of SMAD4 was investigated in head and neck cancer (HNC) patients.
Journal ArticleDOI
LncRNA NCK1-AS1 in plasma distinguishes oral ulcer from early-stage oral squamous cell carcinoma
TL;DR: NCK1-AS1 may promote the metastasis of OSCC by downregulating miR-100, which is characterized as a key player in cervical cancer, while its role in OSCC is unknown.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
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TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
TL;DR: In this article, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomere catalytic subunit.
Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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