Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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S100 proteins in cancer
TL;DR: Emerging in vivo evidence indicates that the biology of most S100 proteins is complex and multifactorial, and that these proteins actively contribute to tumorigenic processes such as cell proliferation, metastasis, angiogenesis and immune evasion.
Journal ArticleDOI
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
Dohun Pyeon,Michael A. Newton,Paul F. Lambert,Johan A. den Boon,Srikumar Sengupta,Carmen J. Marsit,Craig D. Woodworth,Joseph P. Connor,Thomas H. Haugen,Elaine M. Smith,Karl T. Kelsey,Lubomir P. Turek,Paul Ahlquist +12 more
TL;DR: Findings in primary human tumors provide novel biomarkers for early detection of HPV(+) and HPV(-) cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV (+) cancers.
Journal ArticleDOI
NF-κB addiction and its role in cancer: ‘one size does not fit all’
TL;DR: Multiple mechanisms of NF-κB activation and their regulation by multitargeted agent in contrast to monotargeted agents are discussed, thus ‘one size does not fit all’ cancers.
Journal ArticleDOI
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo,Panomwat Amornphimoltham,Cristiane H. Squarize,Rogerio M. Castilho,Vyomesh Patel,J. Silvio Gutkind +5 more
TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.
Journal ArticleDOI
Optimal treatment for recurrent/metastatic head and neck cancer
Jan B. Vermorken,Pol Specenier +1 more
TL;DR: A recent European randomized trial showed that adding cetuximab, the first clinically available EGFR-directed monoclonal antibody, to a standard chemotherapy regimen (platinum/5-fluorouracil) leads to an important survival benefit and this, with support of an additional smaller study in the US, has changed practice.
References
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Journal ArticleDOI
Multiple head and neck tumors frequently originate from a single preneoplastic lesion.
Maarten P. Tabor,Ruud H. Brakenhoff,Henrique J. Ruijter-Schippers,Jacqueline E. van der Wal,G. B. Snow,C. René Leemans,Boudewijn J.M. Braakhuis +6 more
TL;DR: Whether first and second primary tumors are clonally related and originate from a single genetically altered field is determined and a proportion of multiple primary tumors have developed within a single preneoplastic field.
Journal ArticleDOI
Variability of Antioxidant-Related Gene Expression in the Airway Epithelium of Cigarette Smokers
Neil R. Hackett,Adriana Heguy,Ben-Gary Harvey,Timothy O'Connor,Karsta Luettich,Douglas B. Flieder,Rana Kaplan,Ronald G. Crystal +7 more
TL;DR: It is proposed that the antioxidant-related genes demonstrating the most variability in the level of expression in smokers may be useful genetic markers in epidemiologic studies assessing susceptibility to smoking-induced chronic bronchitis.
Journal ArticleDOI
Expressions of Matrix Metalloproteinases in Early-Stage Oral Squamous Cell Carcinoma as Predictive Indicators for Tumor Metastases and Prognosis
Akihiro Katayama,Nobuyuki Bandoh,Kan Kishibe,Miki Takahara,Takeshi Ogino,Satoshi Nonaka,Yasuaki Harabuchi +6 more
TL;DR: Expressions of MMP-9 and TIMP-2 have predictive value for tumor metastases and cause-specific survival and high expression of TIMp-2 is the most independent factor for worse prognosis in early-stage oral SCC.
Journal ArticleDOI
Risk factors for oral and pharyngeal cancer in young adults.
Teresa Rodriguez,Teresa Rodriguez,Andrea Altieri,Liliane Chatenoud,Silvano Gallus,Cristina Bosetti,Eva Negri,Silvia Franceschi,Fabio Levi,Renato Talamini,Carlo La Vecchia,Carlo La Vecchia +11 more
TL;DR: Data from two case-control studies from Italy and Switzerland including 137 cases of oral and pharyngeal cancer below age 46 and 298 hospital controls showed that tobacco accounted for 77% of all cancer cases, alcohol for 52, low vegetable consumption for 52%, and the combination of the three factors for 85%.
Journal ArticleDOI
Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-control studies
Gary J. Macfarlane,Gary J. Macfarlane,Tongzhang Zheng,Tongzhang Zheng,James R. Marshall,James R. Marshall,Paolo Boffetta,Paolo Boffetta,S. Niu,John Brasure,John Brasure,F. Merletti,F. Merletti,P. Boyle,P. Boyle +14 more
TL;DR: This combined analysis of data from three large case-control studies of oral cancer confirms the important effect of tobacco in the aetiology of the disease and indicates decreases in risk for everyone could be achieved by encouraging high fruit and vegetable consumption.
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