Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
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S100 proteins in cancer
TL;DR: Emerging in vivo evidence indicates that the biology of most S100 proteins is complex and multifactorial, and that these proteins actively contribute to tumorigenic processes such as cell proliferation, metastasis, angiogenesis and immune evasion.
Journal ArticleDOI
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
Dohun Pyeon,Michael A. Newton,Paul F. Lambert,Johan A. den Boon,Srikumar Sengupta,Carmen J. Marsit,Craig D. Woodworth,Joseph P. Connor,Thomas H. Haugen,Elaine M. Smith,Karl T. Kelsey,Lubomir P. Turek,Paul Ahlquist +12 more
TL;DR: Findings in primary human tumors provide novel biomarkers for early detection of HPV(+) and HPV(-) cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV (+) cancers.
Journal ArticleDOI
NF-κB addiction and its role in cancer: ‘one size does not fit all’
TL;DR: Multiple mechanisms of NF-κB activation and their regulation by multitargeted agent in contrast to monotargeted agents are discussed, thus ‘one size does not fit all’ cancers.
Journal ArticleDOI
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo,Panomwat Amornphimoltham,Cristiane H. Squarize,Rogerio M. Castilho,Vyomesh Patel,J. Silvio Gutkind +5 more
TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.
Journal ArticleDOI
Optimal treatment for recurrent/metastatic head and neck cancer
Jan B. Vermorken,Pol Specenier +1 more
TL;DR: A recent European randomized trial showed that adding cetuximab, the first clinically available EGFR-directed monoclonal antibody, to a standard chemotherapy regimen (platinum/5-fluorouracil) leads to an important survival benefit and this, with support of an additional smaller study in the US, has changed practice.
References
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Journal ArticleDOI
Multiple primary tumours in oral cancer.
TL;DR: Routine panendoscopy in oral cancer seems not valid and would not have contributed to an earlier diagnosis, and 4 tumours found were synchronous.
Journal Article
p16 and p53 protein expression as prognostic indicators of survival and disease recurrence from head and neck cancer
Stacy A. Geisler,Andrew F. Olshan,Mark C. Weissler,Jainwen Cai,William K. Funkhouser,Joanna Smith,Katie Vick +6 more
TL;DR: The relationship between p53 protein expression and radiation therapy is also unclear as mentioned in this paper, however, p53 expression was found to violate the proportional hazards assumption for their cohort, which may explain the controversial prognostic ability of this protein in the literature.
Journal Article
The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis.
TL;DR: Molecular targeting of COX-2, PGE(2) synthase, or PGE (2) receptors may be useful as a chemopreventive or therapeutic strategy for oral cancer.
Journal ArticleDOI
Betel, tobacco, and cancer of the mouth.
C. S. Muir,R. Kirk +1 more
TL;DR: In this article, the authors propose a method to solve the problem of "missing links" in a graph.Figs. 6-10, 11-15, and 1-5
Journal ArticleDOI
Expression of vascular endothelial growth factor and prognosis of oral squamous cell carcinoma
Masataka Uehara,Kazuo Sano,Hisazumi Ikeda,Joji Sekine,Akihiko Irie,Tomohisa Yokota,Takayoshi Tobita,Seigo Ohba,Tsugio Inokuchi +8 more
TL;DR: Investigation of the correlation between expression of vascular endothelial growth factor (VEGF) and prognosis for oral squamous cell carcinoma found the value of VEGF expression was significantly higher for the patients with poor prognosis than for those with good prognosis.
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