Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
S100 proteins in cancer
TL;DR: Emerging in vivo evidence indicates that the biology of most S100 proteins is complex and multifactorial, and that these proteins actively contribute to tumorigenic processes such as cell proliferation, metastasis, angiogenesis and immune evasion.
Journal ArticleDOI
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
Dohun Pyeon,Michael A. Newton,Paul F. Lambert,Johan A. den Boon,Srikumar Sengupta,Carmen J. Marsit,Craig D. Woodworth,Joseph P. Connor,Thomas H. Haugen,Elaine M. Smith,Karl T. Kelsey,Lubomir P. Turek,Paul Ahlquist +12 more
TL;DR: Findings in primary human tumors provide novel biomarkers for early detection of HPV(+) and HPV(-) cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV (+) cancers.
Journal ArticleDOI
NF-κB addiction and its role in cancer: ‘one size does not fit all’
TL;DR: Multiple mechanisms of NF-κB activation and their regulation by multitargeted agent in contrast to monotargeted agents are discussed, thus ‘one size does not fit all’ cancers.
Journal ArticleDOI
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo,Panomwat Amornphimoltham,Cristiane H. Squarize,Rogerio M. Castilho,Vyomesh Patel,J. Silvio Gutkind +5 more
TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.
Journal ArticleDOI
Optimal treatment for recurrent/metastatic head and neck cancer
Jan B. Vermorken,Pol Specenier +1 more
TL;DR: A recent European randomized trial showed that adding cetuximab, the first clinically available EGFR-directed monoclonal antibody, to a standard chemotherapy regimen (platinum/5-fluorouracil) leads to an important survival benefit and this, with support of an additional smaller study in the US, has changed practice.
References
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Journal ArticleDOI
Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma.
Satoru Shintani,Chunnan Li,Tohru Ishikawa,Mariko Mihara,Koh-ichi Nakashiro,Hiroyuki Hamakawa +5 more
TL;DR: Findings suggest a possible relationship between the expression level of VEGF C and/or D and development of lymphatic tumor spread and a correlation between V EGF A and B expression and tumor angiogenesis.
Journal Article
Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues.
Li Mao,Adel K. El-Naggar,You Hong Fan,Jin Soo Lee,Scott M. Lippman,Scott Kayser,Reuben Lotan,Waun Ki Hong +7 more
TL;DR: The data indicate that activation of telomerase activity is frequent in HNSCC and may occur early in the tumorigenesis process, suggesting that the reactivation of telomersase may be a useful marker for cancer risk assessment in the oral cavity.
Journal Article
A Transcriptional Progression Model for Head and Neck Cancer
Patrick K. Ha,Nicole Benoit,Robert Yochem,James J. Sciubba,Marianna Zahurak,David Sidransky,Jonathan Pevsner,William H. Westra,Joseph A. Califano +8 more
TL;DR: In this article, a genetic progression model for head and neck squamous cell carcinoma (HNSC) has been established and implies the presence of transcriptional dysregulation as a consequence of accumulation of genetic alterations.
Journal ArticleDOI
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Julie E. Burns,M C Baird,L. J. Clark,P A Burns,Edington Kg,C Chapman,R. Mitchell,G. Robertson,D. Soutar,E. K. Parkinson +9 more
TL;DR: Using immunocytochemical and Western blotting techniques, it is demonstrated the presence of abnormally high levels of p53 protein in 8/24 (33%) of human squamous cell carcinomas (SCC) and 9/18 (50%) of SCC cell lines.
Journal ArticleDOI
Biochemoprevention for dysplastic lesions of the upper aerodigestive tract.
Vali Papadimitrakopoulou,Gary L. Clayman,Dong M. Shin,Jeffrey N. Myers,Ann M. Gillenwater,Helmuth Goepfert,Adel K. El-Naggar,Jan S. Lewin,Scott M. Lippman,Waun Ki Hong +9 more
TL;DR: Biochemoprevention is a promising biologic approach for laryngeal dysplasia and needs to be investigated further.
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