Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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E3 ubiquitin ligases: A therapeutic drug target in head and neck squamous cell carcinoma.
Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München Identifizierung, Validierung und funktionelle Charakterisierung spezifischer Tumormarker für Karzinome des Kopf- Hals-Bereiches
TL;DR: The Autoantibody-mediated identification of antigens (AMIDA) as mentioned in this paper is a bestehende Technologie zur Identifizierung von Tumorantigenen weiterentwickelt and optimiert werden.
Journal ArticleDOI
Prognostic value of the immunohistochemical score based on four markers in head and neck squamous cell carcinoma
Qingsheng Xu,Qing-Jie Li,Zhen Xu,Li Lan,Zan Hou,Juan Liu,Lixia Lu,Yuanyuan Chen,Run Chen,Xin Wen +9 more
TL;DR: In this paper , a model for predicting prognosis based on immunohistochemical (IHC) scores was established for head and neck squamous cell carcinoma (HNSCC) using a multivariate Cox regression analysis.
Journal ArticleDOI
Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients.
TL;DR: The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.
References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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