Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
Proteases and HPV-Induced Carcinogenesis
Gabriel Viliod Vieira,Fernanda Somera dos Santos,Ana Paula Lepique,Carol Kobori da Fonseca,Lara Maria Alencar Ramos Innocentini,Paulo Henrique Braz-Silva,Silvana Maria Quintana,Katiuchia Uzzun Sales +7 more
TL;DR: This review highlights the most crucial mechanisms involved in HPV-dependent carcinogenesis, and includes a section on the proteolytic cascades that are important for the progression of this disease and their impact on patient health, treatment, and survival.
Journal ArticleDOI
Early findings of a novel established molecular diagnostic technique for the prediction of malignant transformation in leukoplakia.
Jutta Ries,Sabine Ponader,Nur Mollaoglu,Eleftherios Vairaktaris,Friedrich Wilhelm Neukam,Emeka Nkenke +5 more
TL;DR: In this paper, expression analysis of melanoma-associated antigens (MAGE-A) can differentiate between healthy and already malignant transformed tissues, which can also be used as an additional diagnostic tool for oral pre-malignant lesions to monitor potential malignant changes.
Journal ArticleDOI
Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia
K Ranganath,Allen L. Feng,Ramon A. Franco,Mark A. Varvares,William C. Faquin,Matthew R. Naunheim,Srinivas Vinod Saladi +6 more
TL;DR: In this article , the most frequently altered tumor molecular biomarkers present in head and neck dysplasia as well as their potential clinical applications are comprehensively reviewed. But, the authors do not discuss the use of these biomarkers in clinical decision-making.
Book ChapterDOI
Oral Cancer: Recent Developments and Future Challenges
TL;DR: There is now abundant evidence from large-scale genetics projects and in vitro cell culture work that nearly all oral SCCs bypass senescence and crisis, thus avoiding immune surveillance and at the same time generating a background for tumour heterogeneity.
Journal ArticleDOI
The Role of Periodontopathogens and Oral Microbiome in the Progression of Oral Cancer. A Review
TL;DR: It was showed that genes involved in bacterial chemotaxis, the lipopolysaccharide (LPS) of the cell wall membrane of gram negatives bacteria, were significantly increased in patients with OSCC.
References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
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TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
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Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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