Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
S100 proteins in cancer
TL;DR: Emerging in vivo evidence indicates that the biology of most S100 proteins is complex and multifactorial, and that these proteins actively contribute to tumorigenic processes such as cell proliferation, metastasis, angiogenesis and immune evasion.
Journal ArticleDOI
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
Dohun Pyeon,Michael A. Newton,Paul F. Lambert,Johan A. den Boon,Srikumar Sengupta,Carmen J. Marsit,Craig D. Woodworth,Joseph P. Connor,Thomas H. Haugen,Elaine M. Smith,Karl T. Kelsey,Lubomir P. Turek,Paul Ahlquist +12 more
TL;DR: Findings in primary human tumors provide novel biomarkers for early detection of HPV(+) and HPV(-) cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV (+) cancers.
Journal ArticleDOI
NF-κB addiction and its role in cancer: ‘one size does not fit all’
TL;DR: Multiple mechanisms of NF-κB activation and their regulation by multitargeted agent in contrast to monotargeted agents are discussed, thus ‘one size does not fit all’ cancers.
Journal ArticleDOI
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo,Panomwat Amornphimoltham,Cristiane H. Squarize,Rogerio M. Castilho,Vyomesh Patel,J. Silvio Gutkind +5 more
TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.
Journal ArticleDOI
Optimal treatment for recurrent/metastatic head and neck cancer
Jan B. Vermorken,Pol Specenier +1 more
TL;DR: A recent European randomized trial showed that adding cetuximab, the first clinically available EGFR-directed monoclonal antibody, to a standard chemotherapy regimen (platinum/5-fluorouracil) leads to an important survival benefit and this, with support of an additional smaller study in the US, has changed practice.
References
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Journal ArticleDOI
Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression
Christine H. Chung,Joel S. Parker,Gamze Karaca,Junyuan Wu,William K. Funkhouser,Dominic T. Moore,Dale Butterfoss,Dong Xiang,Adam M. Zanation,Xiaoying Yin,William W. Shockley,Mark C. Weissler,Lynn G. Dressler,Carol G. Shores,Wendell G. Yarbrough,Charles M. Perou +15 more
TL;DR: It is shown that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes, which showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature.
Journal ArticleDOI
A genetic progression model for head and neck cancer: Implications for field cancerization
Joseph A. Califano,Gary L. Clayman,David Sidransky,Wayne M. Koch,Steven Piantadosi,Peter van der Riet,Homaira Nawroz,William H. Westra,Russell L. Corio +8 more
TL;DR: Local clinical phenomenon of field cancerization seems to involve the expansion and migration of clonally related preneoplastic cells surrounding preinvasive and microinvasive lesions, and thus appear to arise from a single progenitor clone.
Journal ArticleDOI
Effects of cigarette smoke on the human airway epithelial cell transcriptome
Avrum Spira,Jennifer Beane,Vishal Shah,Gang Liu,Frank Schembri,Xuemei Yang,John F. Palma,Jerome S. Brody +7 more
TL;DR: The persistent altered expression of a subset of genes in former smokers may explain the risk these individuals have for developing lung cancer long after they have discontinued smoking.
Journal Article
Gene Promoter Hypermethylation in Tumors and Serum of Head and Neck Cancer Patients
Montserrat Sanchez-Cespedes,Manel Esteller,Li Wu,Homaira Nawroz-Danish,George H. Yoo,Wayne M. Koch,Jin Jen,James G. Herman,David Sidransky +8 more
TL;DR: A statistically significant correlation between the presence of DAP-kinase gene promoter hypermethylation and lymph node involvement and advanced disease stage is detected and represents a promising serum marker for monitoring affected patients.
Journal ArticleDOI
Stem cells of the skin epithelium.
Laura C. Alonso,Elaine Fuchs +1 more
TL;DR: Difficult to identify and characterize in any tissue, these cells are nonetheless hotly pursued because they hold the potential promise of therapeutic reprogramming to grow human tissue in vitro, for the treatment of human disease.
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