Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
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S100 proteins in cancer
TL;DR: Emerging in vivo evidence indicates that the biology of most S100 proteins is complex and multifactorial, and that these proteins actively contribute to tumorigenic processes such as cell proliferation, metastasis, angiogenesis and immune evasion.
Journal ArticleDOI
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
Dohun Pyeon,Michael A. Newton,Paul F. Lambert,Johan A. den Boon,Srikumar Sengupta,Carmen J. Marsit,Craig D. Woodworth,Joseph P. Connor,Thomas H. Haugen,Elaine M. Smith,Karl T. Kelsey,Lubomir P. Turek,Paul Ahlquist +12 more
TL;DR: Findings in primary human tumors provide novel biomarkers for early detection of HPV(+) and HPV(-) cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV (+) cancers.
Journal ArticleDOI
NF-κB addiction and its role in cancer: ‘one size does not fit all’
TL;DR: Multiple mechanisms of NF-κB activation and their regulation by multitargeted agent in contrast to monotargeted agents are discussed, thus ‘one size does not fit all’ cancers.
Journal ArticleDOI
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo,Panomwat Amornphimoltham,Cristiane H. Squarize,Rogerio M. Castilho,Vyomesh Patel,J. Silvio Gutkind +5 more
TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.
Journal ArticleDOI
Optimal treatment for recurrent/metastatic head and neck cancer
Jan B. Vermorken,Pol Specenier +1 more
TL;DR: A recent European randomized trial showed that adding cetuximab, the first clinically available EGFR-directed monoclonal antibody, to a standard chemotherapy regimen (platinum/5-fluorouracil) leads to an important survival benefit and this, with support of an additional smaller study in the US, has changed practice.
References
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Journal ArticleDOI
COX-2 inhibition in upper aerodigestive tract tumors.
TL;DR: Clinical studies have been initiated to determine the chemoprotective effects of selective COX-2 inhibitors in patients with oral leukoplakia and Barrett's esophagus, and other studies are assessing the feasibility of incorporating these agents into existing treatment modalities for patients with locally advanced or metastatic cancer.
Journal ArticleDOI
Loss of Fhit expression in head and neck squamous cell carcinoma and its potential clinical implication
Shyh Kuan Tai,Janet I. Lee,K. Kian Ang,Adel K. El-Naggar,Khaled A. Hassan,Diane Liu,J. Jack Lee,Hening Ren,Waun Ki Hong,Li Mao +9 more
TL;DR: Investigation of the Fhit protein expression status in patients with head and neck squamous cell carcinoma found that tumors lacking Fhit expression may be more sensitive to PORT and therefore more susceptible to locoregional control.
Journal Article
Cell culture in esophageal squamous cell carcinoma and the association with molecular markers.
Yutaka Shimada,Masato Maeda,Go Watanabe,Seiji Yamasaki,Izumi Komoto,Junichi Kaganoi,Takatsugu Kan,Yosuke Hashimoto,Issei Imoto,Johji Inazawa,Masayuki Imamura +10 more
TL;DR: Cell culture capability is a significant prognostic factor in ESCC and p53 and MDM2 may have a crucial role in the establishment of ESCC cell lines.
Journal ArticleDOI
The association of white lesions with oral squamous cell carcinoma. A retrospective study of 212 patients.
TL;DR: A series of 212 patients with a histologically proven squamous cell carcinoma of the oral cavity has been studied for the coexistence of white lesions, finding such lesions found in 48% of the patients, more often in women than in men.
Journal ArticleDOI
NSAIDs for the chemoprevention of oral cancer: promise or pessimism?: Commentary re J. L. Mulshine et al., randomized, double-blind, placebo-controlled, phase IIB trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia. Clin. Cancer Res., 10: 1565-1573, 2004.
Susan Goodin,Steven J. Shiff +1 more
TL;DR: Oral cancer causes considerable morbidity and is associated with a 5-year survival rate of less than 50%.
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