Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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The determination of the levels of circulating galectin-1 and -3 in HNSCC patients could be used to monitor tumor progression and/or responses to therapy.
Sven Saussez,Sven Saussez,Francois Lorfevre,Thomas Lequeux,Guy Laurent,Gilbert Chantrain,Françoise Vertongen,Gérard Toubeau,Christine Decaestecker,Robert Kiss +9 more
TL;DR: To evaluate galectin-1, -3 and -7 serum levels as diagnostic and/or prognostic markers for head and neck squamous cell carcinomas (HNSCCs), ELISA was employed to test sera from 102 patients with H NSCCs and from 38 healthy control volunteers for galect in order to establish a level of discrimination between patients and healthy volunteers.
Journal ArticleDOI
Expression of NF-κB parallels COX-2 expression in oral precancer and cancer: Association with smokeless tobacco
Meenakshi Sawhney,Nidhi Rohatgi,Jatinder Kaur,Shishir Shishodia,Gautam Sethi,Siddhartha Datta Gupta,Suryanaryana V.S. Deo,Nootan Kumar Shukla,Bharat B. Aggarwal,Ranju Ralhan +9 more
TL;DR: In vitro studies demonstrated that NNK may be one of the carcinogenic components of ST (khaini) inducing activation of NF‐κB and COX‐2 in oral precancer and cancer cells, suggesting plausible role in ST‐induced oral carcinogenesis.
Journal ArticleDOI
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer
Jarkko T. Korpi,V Kervinen,H. Maklin,Anu Väänänen,M Lahtinen,Esa Läärä,Ari Ristimäki,Gareth J. Thomas,M. Ylipalosaari,Pirjo Åström,Carlos López-Otín,Timo Sorsa,Saara Kantola,Emma Pirilä,Tuula Salo +14 more
TL;DR: It is proposed that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs.
Journal ArticleDOI
Cancer Stem Cell-Platelet Hybrid Membrane-Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma
Lin-Lin Bu,Lang Rao,Guang-Tao Yu,Lei Chen,Wei-Wei Deng,Jian-Feng Liu,Hao Wu,Qian-Fang Meng,Shishang Guo,Xingzhong Zhao,Wen-Feng Zhang,Guojun Chen,Zhen Gu,Wei Liu,Zhi-Jun Sun +14 more
TL;DR: A platelet–cancer stem cell (CSC) hybrid membrane‐coated iron oxide magnetic nanoparticle (MN) {CSC‐P]MN is presented for the first time for the enhanced photothermal therapy of head and neck squamous cell carcinoma (HNSCC).
Journal ArticleDOI
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
Sara Lindström,Deborah J. Thompson,Andrew D. Paterson,Jingmei Li,Gretchen L. Gierach,Christopher G. Scott,Jennifer Stone,Julie A. Douglas,Isabel dos-Santos-Silva,Pablo Fernández-Navarro,Jajini Verghase,Paula Smith,Judith E. Brown,Robert Luben,Nicholas J. Wareham,Ruth J. F. Loos,John A. Heit,V. Shane Pankratz,Aaron D. Norman,Ellen L. Goode,Julie M. Cunningham,Mariza deAndrade,Robert A. Vierkant,Kamila Czene,Peter A. Fasching,Laura Baglietto,Laura Baglietto,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Kaanan P. Shah,Heang Ping Chan,Mark A. Helvie,Andrew H. Beck,Nicholas W. Knoblauch,Aditi Hazra,David J. Hunter,Peter Kraft,Marina Pollán,Jonine D. Figueroa,Fergus J. Couch,John L. Hopper,Per Hall,Douglas F. Easton,Norman F. Boyd,Celine M. Vachon,Rulla M. Tamimi +46 more
TL;DR: The results from meta-analysis of genome-wide association studies (GWAS) of three mammographic density phenotypes provide further evidence of a shared genetic basis between mammographicdensity and breast cancer and illustrate the power of studying intermediate quantitative phenotypes to identify putative disease susceptibility loci.
References
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Journal ArticleDOI
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
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Journal ArticleDOI
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Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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