Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
Prognostic Significance of Tumor Hypoxia Inducible Factor–1α Expression for Outcome After Radiotherapy in Oropharyngeal Cancer
Priyamal Silva,Nicholas J Slevin,Philip Sloan,Helen R Valentine,Jo Cresswell,W David J Ryder,Patricia M Price,Jarrod J Homer,Catharine M L West +8 more
TL;DR: There are significant differences in radiation therapy outcome within a homogeneous subsite of the oropharynx related to molecular marker expression within head-and-neck squamous cell carcinoma.
Journal ArticleDOI
Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma
Ryoichi Fujii,Yorihisa Imanishi,Katsushi Shibata,Nobuya Sakai,Koji Sakamoto,Seiji Shigetomi,Noboru Habu,Kuninori Otsuka,Yoichiro Sato,Yoshihiro Watanabe,Hiroyuki Ozawa,Toshiki Tomita,Kaori Kameyama,Masato Fujii,Kaoru Ogawa +14 more
TL;DR: Findings suggest that the appropriately selective administration of certain Cox-2 inhibitors may have an anti-metastatic effect through suppression of the EMT by restoring E-cadherin expression.
Book ChapterDOI
9 - Cancer Epigenome
TL;DR: This chapter reviews recent progress in the field and discusses some of the pilot studies that have already established epigenomic analysis as integral part of modern cancer research and present a major step toward personalized treatment of this disease in the future.
Journal ArticleDOI
Chemoprevention of Head and Neck Cancer by Green Tea Extract: EGCG-The Role of EGFR Signaling and "Lipid Raft".
TL;DR: The potential of green tea extract, (-)-epigallocatechin-3-galate (EGCG) in HNSCC chemoprevention is discussed, focusing on two aspects that are provided recently: evidence of clinical efficacy and unique biological effects on “lipid raft” that emerged as an important platform of numerous biophysical functions.
Journal ArticleDOI
Searching for molecular markers in head and neck squamous cell carcinomas (HNSCC) by statistical and bioinformatic analysis of larynx-derived SAGE libraries
Nelson J. F. Silveira,Leonardo Varuzza,Ariane Machado-Lima,Marcelo de Souza Lauretto,Daniel Guariz Pinheiro,Rodrigo V. Rodrigues,Rodrigo V. Rodrigues,Patrícia Severino,Francisco G. Nobrega,Wilson A. Silva,Carlos Eduardo Pereira,Eloiza H. Tajara,Eloiza H. Tajara +12 more
TL;DR: The average 5-year survival rate of head and neck squamous cell carcinoma (HNSCC) is one of the lowest among aggressive cancers, showing no significant improvement in recent years.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
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Journal ArticleDOI
Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
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Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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