Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
S100 proteins in cancer
TL;DR: Emerging in vivo evidence indicates that the biology of most S100 proteins is complex and multifactorial, and that these proteins actively contribute to tumorigenic processes such as cell proliferation, metastasis, angiogenesis and immune evasion.
Journal ArticleDOI
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
Dohun Pyeon,Michael A. Newton,Paul F. Lambert,Johan A. den Boon,Srikumar Sengupta,Carmen J. Marsit,Craig D. Woodworth,Joseph P. Connor,Thomas H. Haugen,Elaine M. Smith,Karl T. Kelsey,Lubomir P. Turek,Paul Ahlquist +12 more
TL;DR: Findings in primary human tumors provide novel biomarkers for early detection of HPV(+) and HPV(-) cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV (+) cancers.
Journal ArticleDOI
NF-κB addiction and its role in cancer: ‘one size does not fit all’
TL;DR: Multiple mechanisms of NF-κB activation and their regulation by multitargeted agent in contrast to monotargeted agents are discussed, thus ‘one size does not fit all’ cancers.
Journal ArticleDOI
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo,Panomwat Amornphimoltham,Cristiane H. Squarize,Rogerio M. Castilho,Vyomesh Patel,J. Silvio Gutkind +5 more
TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.
Journal ArticleDOI
Optimal treatment for recurrent/metastatic head and neck cancer
Jan B. Vermorken,Pol Specenier +1 more
TL;DR: A recent European randomized trial showed that adding cetuximab, the first clinically available EGFR-directed monoclonal antibody, to a standard chemotherapy regimen (platinum/5-fluorouracil) leads to an important survival benefit and this, with support of an additional smaller study in the US, has changed practice.
References
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Detection of rare disseminated tumour cells identifies head and neck cancer patients at risk of treatment failure
M. Partridge,Ruud H. Brakenhoff,E Phillips,K Ali,R F R Hooper,K.M. Lavery,Amy Louise Brown,John D. Langdon +7 more
Journal Article
Detection of Rare Disseminated Tumor Cells Identifies Head and Neck Cancer Patients at Risk of Treatment Failure
M. Partridge,Ruud H. Brakenhoff,E. Phillips,Kulsan Ali,Rebecca Francis,Richard Hooper,K.M. Lavery,A.E. Brown,John Langdon +8 more
TL;DR: It is suggested that detection of DTCs pre- or intraoperatively indicates a high risk of local and distant recurrence and reduced survival in head and neck cancer.
Journal ArticleDOI
Tumor promotion by abrasion induced epidermal hyperplasia in the skin of mice
TL;DR: The data demonstrate that regenerative epidermal hyperplasia, of a sufficient intensity, can act as a tumor promoter.
Journal ArticleDOI
Novel regions of amplification on 8q distinct from the MYC locus and frequently altered in oral dysplasia and cancer.
Cathie Garnis,Bradley P. Coe,Bradley P. Coe,Adrian Ishkanian,Lewei Zhang,Miriam P. Rosin,Miriam P. Rosin,Wan L. Lam,Wan L. Lam +8 more
TL;DR: A randomly amplified polymorphic DNA (RAPD)‐PCR approach to fingerprint DNA from microdissected normal and dysplastic cells is used and two recurrent genetic alterations on the long arm of chromosome 8 in OPLs are identified, one mapping to 8q22 and the other to8q24 near the MYC locus.
Journal ArticleDOI
Expression of EGFR and Cerb-B2 as prognostic factors in cancer of the tongue
David Ulanovski,Yoram Stern,Yoram Stern,Pepy Roizman,Pepy Roizman,Thomas Shpitzer,Thomas Shpitzer,Aharon Popovtzer,Aharon Popovtzer,Raphael Feinmesser,Raphael Feinmesser +10 more
TL;DR: Overexpression of EGFR and Cerb-B2 cannot serve as a prognostic factor or predictor of survival and treatment success in SCC of the tongue, as with other epithelial malignancies.
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