Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC)
Rudolf Reiter,Peter Gais,Miriam K. Steuer-Vogt,Anne-Laure Boulesteix,Tom Deutschle,Regina Hampel,Stefan Wagenpfeil,Sandra Rauser,Axel Walch,Karin Bink,Uta Jütting,Frauke Neff,Wolfgang Arnold,Heinz Höfler,Anja Pickhard +14 more
TL;DR: Numerical and structural centrosome abnormalities play a critical role in the tumor progression of in head and neck squamous cell carcinoma (HNSCC) and may provide useful information as a prognostic factor for these patients.
Journal ArticleDOI
Ninein-like protein is overexpressed in head and neck squamous cell carcinoma and contributes to cancer growth and resistance to apoptosis.
TL;DR: Results suggest a novel mechanism that is closely related to malignant phenotype and anti-cancer drugs resistance of HNSCC and support the notion that Nlp overexpression might contribute to the development of H NSCC.
Journal Article
An in vitro multistep carcinogenesis model for both HPV-positive and -negative human oral squamous cell carcinomas.
Yusuke Zushi,Mako Narisawa-Saito,Kazuma Noguchi,Yuki Yoshimatsu,Takashi Yugawa,Nagayasu Egawa,Masatoshi Fujita,Masahiro Urade,Tohru Kiyono +8 more
TL;DR: In this article, the authors transduced either HPV16 E6/E7 or mutant CDK4 (CDK4(R24C)), cyclin D1 and human telomerase reverse transcriptase (TERT) into primary human tongue keratinocytes (HTK), and obtained immortal cell populations, HTK-16E6E7 and HTKK4DT.
Journal ArticleDOI
A novel Multiple-Marker Method for the Early Diagnosis of Oral Squamous Cell Carcinoma
Jutta Ries,Nur Mollaoglu,Takeshi Toyoshima,Eleftherios Vairaktaris,Friedrich Wilhelm Neukam,Sabine Ponader,Emeka Nkenke +6 more
TL;DR: Melanoma associated antigens-A (MAGE-A) expression is highly specific to cancer cells and can be the most suitable targets for the diagnosis of malignancy, according to this study.
Journal ArticleDOI
X-ray radiation promotes the metastatic potential of tongue squamous cell carcinoma cells via modulation of biomechanical and cytoskeletal properties
Qiusheng Zheng,Yang Liu,HJ Zhou,Yuting Du,Baoping Zhang,Jian Zhang,Guoying Miao,Bin Liu,Hong Zhang +8 more
TL;DR: X-ray irradiation enhanced migration and invasiveness in Tca-8113 TSCC cells by altering their biomechanical properties and the organization of the actin cytoskeleton.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
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Journal ArticleDOI
Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
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Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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