Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
Associated risk of XRCC1 and XPD cross talk and life style factors in progression of head and neck cancer in north Indian population
TL;DR: Positive association of XPD Arg751Gln polymorphism with an increased risk of SCCHN is demonstrated and high degree of gene-gene interaction involving DNA repair genes of NER and BER pathways, namely XRCC1 and XPD is demonstrated.
Journal ArticleDOI
Grape seed proanthocyanidins inhibit the invasive potential of head and neck cutaneous squamous cell carcinoma cells by targeting EGFR expression and epithelial-to-mesenchymal transition
TL;DR: Results indicate that grape seed proanthocyanidins have the ability to inhibit the invasion of human cutaneous HNSCC cells by targeting the EGFR expression and reversing the process of epithelial-to-mesenchymal transition.
Journal ArticleDOI
Prediction of outcome of patients with oral squamous cell carcinoma using vascular invasion and the strongly positive expression of vascular endothelial growth factors
Sachiko Seki,Mutsunori Fujiwara,Masaaki Matsuura,Shuichi Fujita,Hisazumi Ikeda,Izumi Asahina,Tohru Ikeda +6 more
TL;DR: Factors related to prognosis are examined to improve the accuracy of prognostic prediction of OSCC using vasculogenesis-associated markers and the presence of vascular invasion or lymph node metastasis was confirmed to be significantly associated with poor prognosis in the univariate analysis.
Journal ArticleDOI
The maintenance of an oral epithelial barrier.
TL;DR: Mechanisms governing the maintenance of oral epithelial barrier are discussed and the role of oral endothelial barrier failure in oral carcinogenesis will also be talked about.
Journal ArticleDOI
The stem cell hypothesis in head and neck cancer.
TL;DR: The evidence that the development of a tumor comes from a small number of cells with stem‐like characteristic, could bring too to the identification of therapies against these cellular target, fundamental for maintenance and progression of the lesion.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
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Journal ArticleDOI
Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
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Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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