Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal Article
Antitumor Effect of Novel HSP90 Inhibitor NVP-AUY922 against Oral Squamous Cell Carcinoma
Tatsuo Okui,Tsuyoshi Shimo,Nur Mohammad Monsur Hassan,Takuya Fukazawa,Naito Kurio,Munenori Takaoka,Yoshio Naomoto,Akira Sasaki +7 more
TL;DR: This study investigated the antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma and exhibits in vitro and in vivo efficiency against oralSquamouscell carcinoma, representing a promising therapeutic approach for oral Squamous Cell carcinoma.
Journal ArticleDOI
MiR-132 plays an oncogenic role in laryngeal squamous cell carcinoma by targeting FOXO1 and activating the PI3K/AKT pathway.
TL;DR: It is demonstrated that miR-132 plays an important oncogenic role in LSCC by modulating the PI3K/AKT/FOXO1 pathway at multiple levels, resulting in strong prognostic implication.
Journal ArticleDOI
The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development.
TL;DR: The influence of low-penetrance polymorphisms in the genes along the GH1/IGF-1 axis and their impact on hormone levels and cancer risk, especially breast cancer are discussed.
Journal ArticleDOI
FADD expression is associated with regional and distant metastasis in squamous cell carcinoma of the head and neck
W. J. Pattje,Lieuwe J. Melchers,Lorian Slagter-Menkema,Mirjam F. Mastik,Michiel L Schrijvers,Johan H. Gibcus,Philippus Kluin,O Hoegen-Chouvalova,van der Bernard Laan,Jan L. N. Roodenburg,J.E. van der Wal,Ed Schuuring,Johannes A. Langendijk +12 more
TL;DR: The aim of this study was to investigate the association between FADD protein expression in advanced‐stage HNSCC and clinicopathological features and outcome.
Journal ArticleDOI
Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens.
Brian J. Morris,Barbara Rose +1 more
TL;DR: A kit for self-collection and return to a testing laboratory, followed by practitioner notification and follow-up if required, should result in wider participation and the higher accuracy of HPV testing should lead to improved cervical cancer prevention.
References
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Journal ArticleDOI
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
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TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
TL;DR: In this article, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomere catalytic subunit.
Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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