Journal ArticleDOI
Profiling early head and neck cancer.
TLDR
Prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer.Abstract:
Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a severe impact on the quality of life of patients and survivors, and the significant morbidity subsequent to treatment often mandates long-term multidisciplinary care, which places significant financial pressures on the treating institution. Therefore, prevention and early diagnosis of high-risk pre-malignant lesions are high priorities for reducing deaths due to head and neck cancer. Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy.read more
Citations
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Journal ArticleDOI
Prognostic and predictive markers for oral squamous cell carcinoma: The importance of clinical, pathological and molecular markers
TL;DR: The overall 5-year survival rate following treatment for oral squamous cell carcinoma is around 50% in most published series, and early detection results in better prognosis in most cases.
Journal ArticleDOI
PI3K/PTEN/AKT/mTOR polymorphisms: association with clinical outcome in patients with head and neck squamous cell carcinoma receiving cetuximab-docetaxel.
Katharina Pfisterer,Alberto Fusi,Konrad Klinghammer,Maren Knödler,Anika Nonnenmacher,Ulrich Keilholz +5 more
TL;DR: The purpose of this study was to determine whether single nucleotide polymorphisms in AKT1, AKT2, FRAP1, PIK3CA, and PTEN were associated with treatment response and clinical outcome in patients with head and neck squamous cell carcinoma (HNSCC).
Journal ArticleDOI
Expression of a novel marker, Ubc9, in squamous cell carcinoma of the head and neck.
Ohad Ronen,James Malone,Paul Kay,Christopher M. Bivens,Kelly Hall,Lakshmi P. Paruchuri,Yin-yuan Mo,K. Thomas Robbins,Sophia Ran +8 more
TL;DR: The objective of this study was to determine the expression of Ubc9 in squamous cell carcinoma of the head and neck (SCCHN) and to investigate the role of Ubiquitin‐conjugating enzyme in this cancer.
Journal ArticleDOI
Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines
Joel Greshock,Jie Cheng,David W. Rusnak,Anne-Marie Martin,Richard Wooster,Tona M. Gilmer,Kwan Lee,Barbara L. Weber,Tal Zaks +8 more
TL;DR: This study shows that biomarkers predictive for lapatinib sensitivity, including the previously described copy number gains of EGFR and HER2, can be discovered using novel genomic assays in an unbiased manner, and shows the utility of DNA copy number profiles in pharmacogenomic studies.
Journal ArticleDOI
Urinary-Type Plasminogen Activator Receptor/α3β1 Integrin Signaling, Altered Gene Expression, and Oral Tumor Progression
Supurna Ghosh,Jennifer E. Koblinski,Jeff Johnson,Yueying Liu,Aaron C. Ericsson,J. Wade Davis,Zonggao Shi,Matthew J. Ravosa,Susan Crawford,Shellaine Frazier,M. Sharon Stack +10 more
TL;DR: Results support a model wherein increased uPAR expression promotes α3β1 integrin association, resulting in increased mitogen-activated protein kinase signaling and transcriptional activation, leading to the formation of more aggressive tongue tumors.
References
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Journal ArticleDOI
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
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Journal ArticleDOI
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Journal ArticleDOI
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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