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Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo-controlled, crossover, randomised trial and systematic review

Clara K Chow, +29 more
- 11 Mar 2017 - 
- Vol. 389, Iss: 10073, pp 1035-1042
TLDR
The findings of this small trial in the context of previous randomised evidence suggest that the benefits of quarter-dose therapy could be additive across classes and might confer a clinically important reduction in blood pressure.
About: 
This article is published in The Lancet.The article was published on 2017-03-11 and is currently open access. It has received 87 citations till now. The article focuses on the topics: Ambulatory blood pressure & Blood pressure.

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Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension.

Bin Zhou, +3 more
- 28 May 2021 - 
TL;DR: Zhou et al. as discussed by the authors summarized the current data on the global epidemiology of blood pressure and hypertension and evaluate changes over time, and discussed interventions that can reduce the burden of high blood pressure.
Journal ArticleDOI

Reducing the Global Burden of Cardiovascular Disease, Part 2: Prevention and Treatment of Cardiovascular Disease.

Darryl P. Leong, +6 more
- 01 Sep 2017 - 
TL;DR: In this paper, the authors reviewed the proven, effective approaches to the prevention and treatment of cardiovascular disease, including lifestyle factors, blood pressure control, cholesterol-lowering, antithrombotic therapy, and fixed-dose combination therapy.
Journal ArticleDOI

Blood pressure and the new ACC/AHA hypertension guidelines

John M. Flack, +1 more
- 01 Apr 2020 - 
TL;DR: The ACC/AHA hypertension guidelines cover virtually all aspects of the diagnosis, evaluation, monitoring, secondary causes as well as drug and non-drug treatment of hypertension, and breaks new ground with some of its recommendations.
Journal ArticleDOI

Stereolithography (SLA) 3D printing of an antihypertensive polyprintlet: Case study of an unexpected photopolymer-drug reaction

Xiaoyan Xu, +9 more
- 01 May 2020 - 
TL;DR: In this paper, a multi-layer 3D printed oral dosage form (polyprintlet) incorporating four antihypertensive drugs including irbesartan, atenolol, hydrochlorothiazide and amlodipine was used to reduce pill burden and improve patient adherence.
Journal ArticleDOI

Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial.

Ruth Webster, +27 more
- 14 Aug 2018 - 
TL;DR: Treatment with a pill containing low doses of 3 antihypertensive drugs led to an increased proportion of patients achieving their target BP goal vs usual care and use of such medication as initial therapy or to replace monotherapy may be an effective way to improve BP control.
References
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Journal ArticleDOI

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Stephen S Lim, +210 more
- 15 Dec 2012 - 
TL;DR: In this paper, the authors estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010.
Journal ArticleDOI

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

Edmond J Lewis, +9 more
- 20 Sep 2001 - 
TL;DR: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes, independent of the reduction in blood pressure it causes.
Journal ArticleDOI

A Randomized Trial of Intensive versus Standard Blood-Pressure Control

Jackson T. Wright, +18 more
- 26 Nov 2015 - 
TL;DR: In this article, the most appropriate targets for systolic blood pressure to reduce cardiovascular morbidity and mortality among persons without diabetes remain uncertain, and the authors propose a target of less than 120 mm Hg.
Journal ArticleDOI

Effects of intensive blood-pressure control in type 2 diabetes mellitus.

C. Cushman, +12 more
- 29 Apr 2010 - 
TL;DR: In patients with type 2 diabetes at high risk for cardiovascular events, targeting a systolic blood pressure of less than 120 mm HG, as compared with less than 140 mm Hg, did not reduce the rate of a composite outcome of fatal and nonfatal major cardiovascular events.
Journal ArticleDOI

Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies

Malcolm Law, +2 more
- 19 May 2009 - 
TL;DR: All the classes of blood pressure lowering drugs have a similar effect in reducing CHD events and stroke for a given reduction in blood pressure, indicating that the benefit is explained by blood pressure reduction itself.
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2018 ESC/ESH Guidelines for the management of arterial hypertension.

B. Williams, +27 more
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2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).

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2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

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Frequently Asked Questions (1)
Q1. What have the authors contributed in "Quarter-dose quadruple combination therapy for initial treatment of hypertension – a proof-of-concept placebo-controlled crossover randomized trial" ?

The authors examine whether using ultra-low dose quadruple combination therapy provides an 37 approach with greater efficacy and tolerability. The authors conducted a systematic review of trials evaluating the efficacy and safety of quarter39 standard dose BP-lowering therapy against placebo and a randomised, placebo-controlled, double-blind, 40 cross-over trial of a ‘ quadpill ’: a single capsule containing four BP-lowering medicines each at quarter41 dose ( irbesartan 37. Further examination of the quadpill concept is needed to examine effectiveness 58 against usual treatment options and longer term tolerability.