Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France, - January 31st to March 1st, 2020: A respiratory virus snapshot.
Sophie Amrane,Hervé Tissot-Dupont,Barbara Doudier,Carole Eldin,Marie Hocquart,Morgane Mailhe,Pierre Dudouet,Etienne Ormières,Lucie Ailhaud,Philippe Parola,Jean-Christophe Lagier,Philippe Brouqui,Christine Zandotti,Laetitia Ninove,Léa Luciani,Céline Boschi,Bernard La Scola,Didier Raoult,Matthieu Million,Philippe Colson,Philippe Gautret +20 more
TLDR
The first 280 patients suspected to have COVID-19 were managed through a rapid care circuit and virological diagnosis in the authors' infectious disease reference hospital in Marseille, France, and no SARS-CoV-2 was detected.About:
This article is published in Travel Medicine and Infectious Disease.The article was published on 2020-03-20 and is currently open access. It has received 109 citations till now. The article focuses on the topics: Respiratory virus.read more
Citations
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Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
Philippe Gautret,Jean-Christophe Lagier,Philippe Parola,Van Thuan Hoang,Line Meddeb,M. Mailhe,Barbara Doudier,Johan Courjon,Valérie Giordanengo,Vera Esteves Vieira,Hervé Tissot Dupont,Stéphane Honoré,Philippe Colson,Eric Chabrière,Bernard La Scola,Jean-Marc Rolain,Philippe Brouqui,Didier Raoult +17 more
TL;DR: Hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin, which was significantly more efficient for virus elimination.
Journal ArticleDOI
Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
Bernard La Scola,Marion Le Bideau,Julien Andreani,Van Thuan Hoang,Clio Grimaldier,Philippe Colson,Philippe Gautret,Didier Raoult +7 more
TL;DR: Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33–34 using the RT- PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients.
Journal ArticleDOI
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
Philippe Gautret,Jean-Christophe Lagier,Philippe Parola,Van Thuan Hoang,Line Meddeb,Jacques Sevestre,Morgane Mailhe,Barbara Doudier,Camille Aubry,Sophie Amrane,Piseth Seng,Marie Hocquart,Carole Eldin,Julie Finance,Vera Esteves Vieira,Hervé Tissot-Dupont,Stéphane Honoré,Andreas Stein,Matthieu Million,Philippe Colson,Bernard La Scola,Véronique Veit,Alexis Jacquier,Jean Claude Deharo,Michel Drancourt,Pierre-Edouard Fournier,Jean-Marc Rolain,Philippe Brouqui,Didier Raoult +28 more
TL;DR: There is urgency to evaluate the effectiveness of this potentially-life saving therapeutic strategy at a larger scale, both to treat and cure patients at an early stage before irreversible severe respiratory complications take hold and to decrease duration of carriage and avoid the spread of the disease.
Journal ArticleDOI
Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France.
Matthieu Million,Jean-Christophe Lagier,Philippe Gautret,Philippe Colson,Pierre-Edouard Fournier,Sophie Amrane,Marie Hocquart,Morgane Mailhe,Vera Esteves-Vieira,Barbara Doudier,Camille Aubry,Florian Correard,Audrey Giraud-Gatineau,Yanis Roussel,Cyril Berenger,Nadim Cassir,Piseth Seng,Christine Zandotti,Catherine Dhiver,Isabelle Ravaux,Christelle Tomei,Carole Eldin,Hervé Tissot-Dupont,Stéphane Honoré,Andreas Stein,Alexis Jacquier,Jean Claude Deharo,Eric Chabrière,Anthony Levasseur,Florence Fenollar,Jean-Marc Rolain,Yolande Obadia,Philippe Brouqui,Michel Drancourt,Bernard La Scola,Philippe Parola,Didier Raoult +36 more
TL;DR: Administration of the HCQ+AZ combination before COVID-19 complications occur is safe and associated with very low fatality rate in patients, retrospectively report on 1061 SARS-CoV-2 positive tested patients.
Journal ArticleDOI
Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis.
Julien Carvelli,Olivier Demaria,Frédéric Vély,Luciana Batista,Nassima Chouaki Benmansour,Joanna Fares,Sabrina Carpentier,Marie-Laure Thibult,Ariane Morel,Romain Remark,Pascale Andre,Agnès Represa,Christelle Piperoglou,Pierre Yves Cordier,Erwan Le Dault,Christophe Guervilly,Pierre Simeone,Marc Gainnier,Yannis Morel,Mikael Ebbo,Nicolas Schleinitz,Eric Vivier +21 more
TL;DR: Results suggest that blockade of the C5a–C5aR1 axis could be used to limit the infiltration of myeloid cells in damaged organs and prevent the excessive lung inflammation and endothelialitis that are associated with acute respiratory distress syndrome in patients with COVID-19.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
Jasper Fuk-Woo Chan,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Hin Chu,Jin Yang,Fanfan Xing,Jieling Liu,Cyril C. Y. Yip,Rosana W.S. Poon,Hoi Wah Tsoi,Simon Kam Fai Lo,Kwok-Hung Chan,Vincent Kwok-Man Poon,Wan Mui Chan,Jonathan Daniel Ip,Jian Piao Cai,Vincent C.C. Cheng,Honglin Chen,Honglin Chen,Christopher K.M. Hui,Kwok-Yung Yuen +22 more
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.
Victor M. Corman,Olfert Landt,Marco Kaiser,Richard Molenkamp,Adam Meijer,Daniel K.W. Chu,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Marie Luisa Schmidt,Daphne G.J.C. Mulders,Bart L. Haagmans,Bas van der Veer,Sharon van den Brink,Lisa Wijsman,Gabriel Goderski,Jean Louis Romette,Joanna Ellis,Maria Zambon,Malik Peiris,Herman Goossens,Chantal B.E.M. Reusken,Marion Koopmans,Christian Drosten +23 more
TL;DR: A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.
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Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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