Regulation and function of the human HSP90AA1 gene.
TLDR
This article will specifically focus on the expression, function and regulation of Hsp90α, the stress inducible isoform of the molecular chaperone Hsp 90.About:
This article is published in Gene.The article was published on 2015-10-01 and is currently open access. It has received 163 citations till now. The article focuses on the topics: Peptide sequence & Gene isoform.read more
Citations
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Journal ArticleDOI
The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease
TL;DR: This manuscript will review the general structure, regulation and function of HSP90 family and their potential role in pathophysiology.
Journal ArticleDOI
Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons.
Corina Nagy,Malosree Maitra,Arnaud Tanti,Matthew Suderman,Jean-François Théroux,Maria Antonietta Davoli,Kelly Perlman,Volodymyr Yerko,Yu Chang Wang,Shreejoy J. Tripathy,Shreejoy J. Tripathy,Shreejoy J. Tripathy,Paul Pavlidis,Naguib Mechawar,Naguib Mechawar,Jiannis Ragoussis,Gustavo Turecki,Gustavo Turecki,Gustavo Turecki +18 more
TL;DR: Single-nucleus transcriptomics reveals brain alterations associated with major depression, and deep layer excitatory cells and immature oligodendrocytes showed most changes, involving synaptic plasticity, immune function and steroid hormones.
Journal ArticleDOI
Mechanisms of Hsp90 regulation.
TL;DR: This review, looks at the many different levels by which Hsp90 activity is ultimately regulated and some are directly responsible for delivery of client protein.
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Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Emanuel Wyler,Kirstin Mösbauer,Vedran Franke,Asija Diag,Lina Theresa Gottula,Roberto Arsie,Filippos Klironomos,Filippos Klironomos,David Koppstein,Katja Hönzke,Salah Ayoub,Christopher Buccitelli,Karen Hoffmann,Anja Richter,Ivano Legnini,Andranik Ivanov,Tommaso Mari,Simone Del Giudice,Jan Papies,Samantha D. Praktiknjo,Thomas F. Meyer,Marcel A. Müller,Daniela Niemeyer,Andreas C. Hocke,Matthias Selbach,Altuna Akalin,Nikolaus Rajewsky,Christian Drosten,Markus Landthaler,Markus Landthaler +29 more
TL;DR: In this article, gene expression profiles of three SARS-CoV and SARS CoV-2 infected human cell lines were reported, and it was shown that SARS co-virus infection elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS in the human epithelial cell line Calu-3, including induction of miRNA-155.
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Heat Shock Proteins Regulatory Role in Neurodevelopment.
David J. Miller,Patrice Fort +1 more
TL;DR: This review will examine the regulatory role that individual chaperones may play in neurodevelopment, and will focus specifically on the signaling pathways involved in the maturation of neuronal and glial cells as well as the underlying vascular network.
References
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The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami,Jianjiong Gao,Ugur Dogrusoz,Benjamin Gross,Selcuk Onur Sumer,Bulent Arman Aksoy,Anders Jacobsen,Caitlin Byrne,Michael Heuer,Erik G. Larsson,Yevgeniy Antipin,Boris Reva,Arthur P. Goldberg,Chris Sander,Nikolaus Schultz +14 more
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HSP90 and the chaperoning of cancer.
TL;DR: Pharmacologically 'bribing' the essential guard duty of the chaperone HSP90 (heat-shock protein of 90 kDa) seems to offer a unique anticancer strategy of considerable promise.
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AmiGO: online access to ontology and annotation data
Seth Carbon,Amelia Ireland,Christopher J. Mungall,ShengQiang Shu,Brad Marshall,Suzanna E. Lewis +5 more
TL;DR: AmiGO is a web application that allows users to query, browse and visualize ontologies and related gene product annotation (association) data.
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HSP90 at the hub of protein homeostasis: emerging mechanistic insights
TL;DR: Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.