Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy
TLDR
Dilation has a surprisingly modest impact on total blood flow, and so it is suggested the placental pathology associated with deficient conversion is dominated by rheological consequences rather than chronic hypoxia.About:
This article is published in Placenta.The article was published on 2009-06-01 and is currently open access. It has received 938 citations till now. The article focuses on the topics: Intervillous space & Spiral artery.read more
Citations
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Single-cell reconstruction of the early maternal–fetal interface in humans
Roser Vento-Tormo,Roser Vento-Tormo,Mirjana Efremova,Rachel A. Botting,Margherita Y. Turco,Miquel Vento-Tormo,Kerstin B. Meyer,Jong-Eun Park,Emily Stephenson,Krzysztof Polanski,Angela Goncalves,Angela Goncalves,Lucy Gardner,Staffan Holmqvist,Johan Henriksson,Angela Zou,Andrew M. Sharkey,Ben Millar,Barbara A. Innes,Laura Wood,Anna Wilbrey-Clark,Rebecca Payne,Martin A. Ivarsson,Steve Lisgo,Andrew Filby,David H. Rowitch,Judith N. Bulmer,Gavin J. Wright,Michael J. T. Stubbington,Muzlifah Haniffa,Muzlifah Haniffa,Ashley Moffett,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann +34 more
TL;DR: A single-cell atlas of the maternal–fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success, and develops a repository of ligand–receptor complexes and a statistical tool to predict the cell–cell communication via these molecular interactions.
Journal ArticleDOI
Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement
T. Yee Khong,Eoghan E. Mooney,Ilana Ariel,Nathalie C.M. Balmus,Theonia K. Boyd,Marie Anne Brundler,Hayley Derricott,Margaret J. Evans,Ona Faye-Petersen,John Gillan,Alexander E. P. Heazell,Debra S. Heller,Suzanne M. Jacques,Sarah Keating,Peter Kelehan,Ann Maes,Eileen McKay,Terry K. Morgan,Peter G. J. Nikkels,W. Tony Parks,Raymond W. Redline,Irene Scheimberg,Mirthe H. Schoots,Neil J. Sebire,Albert Timmer,Gitta Turowski,J. Patrick van der Voorn,Ineke Van Lijnschoten,Sanne J. Gordijn +28 more
TL;DR: The group agreed on sets of uniform sampling criteria, placental gross descriptors, pathologic terminologies, and diagnostic criteria for placental lesions, which will assist in international comparability of clinicopathologic and scientific studies and assist in refining the significance of lesions associated with adverse pregnancy and later health outcomes.
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Pre-eclampsia part 1: current understanding of its pathophysiology
TL;DR: The diagnosis, classification, clinical manifestations and putative pathogenetic mechanisms of pre-eclampsia are discussed.
Journal ArticleDOI
Pre-eclampsia: pathophysiology and clinical implications
TL;DR: Recent research has focused on placental-uterine interactions in early pregnancy, and the aim now is to translate these findings into new ways to predict, prevent, and treat pre-eclampsia.
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Immunology of Pre-Eclampsia
TL;DR: In this paper, the pathogenesis of pre-eclampsia can be related to defined immune mechanisms that are appropriate to the fetomaternal frontier, and the first pregnancy preponderance and partner specificity can be explained by this model.
References
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Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants.
TL;DR: Findings point to a defect in the normal interaction between migratory trophoblast and maternal uterine tissues in pre‐eclampsia and in SGA, a feature not seen beyond the second trimester in normal pregnancy.
Journal ArticleDOI
Preeclampsia: an excessive maternal inflammatory response to pregnancy.
TL;DR: It is argued that preeclampsia arises when a universal maternal intravascular inflammatory response to pregnancy decompensates in particular cases, which may occur because either the stimulus or the maternal response is too strong.
Journal ArticleDOI
Endovascular Trophoblast Invasion: Implications for the Pathogenesis of Intrauterine Growth Retardation and Preeclampsia
TL;DR: The reviewed data suggest that endovascular trophoblast invasion involves a side route of interstitial invasion, which is associated with maintenance of high uteroplacental vascular resistance and intrauterine growth restriction (IUGR) and preeclampsia.
Journal ArticleDOI
The Uterine Spiral Arteries In Human Pregnancy: Facts and Controversies
TL;DR: Several features of the human placental bed are mirrored by processes in other species with haemochorial placentation, and studying such models may help to illuminate poorly understood aspects of human placenta and fetus.
Book
Obstetrics Normal And Problem Pregnancies
TL;DR: The third edition of this work is a reference guide for a new generation of obstetricians and gynaecologists.
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