SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens.
Liang Peng,Jing Liu,Wenxiong Xu,Qiumin Luo,Dabiao Chen,Ziying Lei,Zhan-Lian Huang,Xuejun Li,Keji Deng,Bingliang Lin,Zhiliang Gao +10 more
TLDR
To detect severe acute respiratory syndrome coronavirus 2 ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS‐CoV‐2 infection, and correlated positive results with clinical findings, testing different specimen types may be useful for monitoring disease changes and progression, and for establishing a prognosis.Abstract:
Purpose The purpose of this study was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS-CoV-2 infection, and correlated positive results with clinical findings. Methods Patients with confirmed SARS-CoV-2 infections were included in this study. Patients' demographic and clinical data were recorded. Quantitative real-time polymerase chain reaction was used to detect SARS-CoV-2 RNA in urine and blood specimens, and anal and oropharyngeal swabs. The study is registered at ClinicalTrials.gov (No. NCT04279782, 19 February, 2020). Results SARS-CoV-2 RNA was present in all four specimen types, though not all specimen types were positive simultaneously. The presence of viral RNA was not necessarily predictive of clinical symptoms, for example, the presence of viral RNA in the urine did not necessarily predict urinary tract symptoms. Conclusions SARS-CoV-2 can infect multiple systems, including the urinary tract. Testing different specimen types may be useful for monitoring disease changes and progression, and for establishing a prognosis.read more
Citations
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Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.
Yuan Liu,Zhi Ning,Yu Chen,Ming Guo,Yingle Liu,Nirmal Kumar Gali,Li Sun,Yusen Duan,Jing Cai,Dane Westerdahl,Xinjin Liu,Ke Xu,Kin Fai Ho,Haidong Kan,Qingyan Fu,Ke Lan +15 more
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The protein expression profile of ACE2 in human tissues.
Feria Hikmet,Loren Méar,Åsa Edvinsson,Patrick Micke,Mathias Uhlén,Mathias Uhlén,Cecilia Lindskog +6 more
TL;DR: The expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis constitutes an important resource for further studies on SARS‐CoV‐2 host cell entry, to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.
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The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
James D. McFadyen,James D. McFadyen,James D. McFadyen,Hannah Stevens,Hannah Stevens,Hannah Stevens,Karlheinz Peter,Karlheinz Peter +7 more
TL;DR: The activation of coagulation (eg, as measured with plasma D-dimer) and thrombocytopenia have emerged as prognostic markers in COVID-19, and strategies to preventThrombotic complications are of critical importance.
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Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.
Urszula Radzikowska,Urszula Radzikowska,Mei Ding,Mei Ding,Ge Tan,Ge Tan,Damir Zhakparov,Yaqi Peng,Paulina Wawrzyniak,Ming Wang,Shuo Li,Hideaki Morita,Can Altunbulakli,Matthias Reiger,Avidan U. Neumann,Avidan U. Neumann,Nonhlanhla Lunjani,Claudia Traidl-Hoffmann,Kari C. Nadeau,Liam O'Mahony,Liam O'Mahony,Cezmi A. Akdis,Milena Sokolowska +22 more
TL;DR: The aim of this study was to analyze the expression of known and potential SARS‐CoV‐2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID‐19.
Posted ContentDOI
The protein expression profile of ACE2 in human tissues
TL;DR: The expression pattern of ACE2 across >150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis constitutes an important resource for further studies on SARS-CoV-2 host cell entry and to aid in the development of effective treatments to the viral infection.
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