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Open AccessJournal ArticleDOI

SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens.

TLDR
To detect severe acute respiratory syndrome coronavirus 2 ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS‐CoV‐2 infection, and correlated positive results with clinical findings, testing different specimen types may be useful for monitoring disease changes and progression, and for establishing a prognosis.
Abstract
Purpose The purpose of this study was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS-CoV-2 infection, and correlated positive results with clinical findings. Methods Patients with confirmed SARS-CoV-2 infections were included in this study. Patients' demographic and clinical data were recorded. Quantitative real-time polymerase chain reaction was used to detect SARS-CoV-2 RNA in urine and blood specimens, and anal and oropharyngeal swabs. The study is registered at ClinicalTrials.gov (No. NCT04279782, 19 February, 2020). Results SARS-CoV-2 RNA was present in all four specimen types, though not all specimen types were positive simultaneously. The presence of viral RNA was not necessarily predictive of clinical symptoms, for example, the presence of viral RNA in the urine did not necessarily predict urinary tract symptoms. Conclusions SARS-CoV-2 can infect multiple systems, including the urinary tract. Testing different specimen types may be useful for monitoring disease changes and progression, and for establishing a prognosis.

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Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.

TL;DR: It is proposed that room ventilation, open space, sanitization of protective apparel, and proper use and disinfection of toilet areas can effectively limit the concentration of SARS-CoV-2 RNA in aerosols, although the infectivity of the virus RNA was not established in this study.
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The protein expression profile of ACE2 in human tissues.

TL;DR: The expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis constitutes an important resource for further studies on SARS‐CoV‐2 host cell entry, to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.
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The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.

TL;DR: The activation of coagulation (eg, as measured with plasma D-dimer) and thrombocytopenia have emerged as prognostic markers in COVID-19, and strategies to preventThrombotic complications are of critical importance.
Posted ContentDOI

The protein expression profile of ACE2 in human tissues

TL;DR: The expression pattern of ACE2 across >150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis constitutes an important resource for further studies on SARS-CoV-2 host cell entry and to aid in the development of effective treatments to the viral infection.
References
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Journal ArticleDOI

First Case of 2019 Novel Coronavirus in the United States.

TL;DR: This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection.
Journal ArticleDOI

Detection of SARS-CoV-2 in Different Types of Clinical Specimens.

TL;DR: Results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China are described to identify possible means of non-respiratory transmission.
Journal ArticleDOI

Middle East respiratory syndrome coronavirus (MERS-CoV): threats, gaps and containment strategies

TL;DR: The disease is following a propagated epidemic curve and trending to more spreading and adding more and more cases, which is considered threatening for coronavirus as the case fatality rate is extremely high and mortality rate can reach up to 50 %.
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